(R)-2-(2,5-dichloro-3-fluorophenyl)pyrrolidine CAS 1213848-83-9
| CAS No. | 1213848-83-9 |
| Molecular Formula | C10H10Cl2FN |
| Molecular Weight | 234.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (R)-2-(2,5-dichloro-3-fluorophenyl)pyrrolidine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies (R)-2-(2,5-dichloro-3-fluorophenyl)pyrrolidine (CAS 1213848-83-9), a certified reference material (molecular formula C10H10Cl2FN, MW 234.10 g/mol) for analytical method development and quality control.
The molecular framework of (R)-2-(2,5-dichloro-3-fluorophenyl)pyrrolidine (C10H10Cl2FN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10Cl2FN |
| Molecular Weight | 234.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related R Standards
- 5,7-Dichloro-2H-benzo[b][1,4]thiazin-3(4H)-one (CAS 100831-31-0)
- 2,4-Dichloro-5-methoxybenzo[d]thiazole (CAS 113206-07-8)
- 1,5-Dichloro-2-isothiocyanato-4-methoxybenzene (CAS 120222-84-6)
- (S)-2-(2,3-dichloro-5-fluorophenyl)pyrrolidine (CAS 1212890-41-9)
- (R)-2-(2,3-dichloro-5-fluorophenyl)pyrrolidine (CAS 1212981-26-4)
- (S)-2-(3,5-dichloro-2-fluorophenyl)pyrrolidine (CAS 1213008-83-3)
- (R)-2-(3,5-dichloro-2-fluorophenyl)pyrrolidine (CAS 1213109-21-7)
- (S)-2-(2,5-dichloro-3-fluorophenyl)pyrrolidine (CAS 1213850-68-0)
Recommended Standards
- 6-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine (CAS 1214242-09-7)
- 4-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine (CAS 1220219-94-2)
- 6-Amino-2-methylpyridine-3-boronic Acid Pinacol Ester (CAS 1220219-97-5)
- 4-(Cyclohexyloxy)methylphenylboronic acid (CAS 1221823-93-3)
- 2,2,5,7-Tetramethyl-1-oxo-2,3-dihydro-1H-indene-4-carboxylic acid (CAS 23342-32-7)
- (3-(Ethoxycarbonyl)-2-fluorophenyl)boronic acid (CAS 1072952-52-3)
- 5-Bromo-3-methyl-6-oxo-1,6-dihydro-pyridine-2-carboxylic acid methyl ester (CAS 1006365-26-9)
- 4-Chloropyrimidine-5-carbonyl chloride (CAS 1261494-35-2)
- N-1-Cyclohexyl-N-1,2-dimethyl-1,4-benzenediamine (CAS 1094497-09-2)
- 4-(3-Chloro-5-methoxyphenyl)piperidine hydrochloride (CAS 2168546-86-7)
- 2-Isopropyl-6-(phenylethynyl)pyridazin-3(2H)-one (CAS 524919-41-3)
- 3-Nitropyridine-2-sulfonyl chloride (CAS 1071524-26-9)
- 2-Propenoic acid, 2-methyl-, polymer with ethenylbenzene, potassium salt (CAS 25068-00-2)
- Insulin Degludec Impurity 9 (CAS CATO-C4X-21579)
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