4-(Difluoromethoxy)-1-fluoro-2-methylbenzene CAS 1214333-46-6
| CAS No. | 1214333-46-6 |
| Molecular Formula | C8H7F3O |
| Molecular Weight | 176.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(Difluoromethoxy)-1-fluoro-2-methylbenzene.
4-(Difluoromethoxy)-1-fluoro-2-methylbenzene (CAS 1214333-46-6), molecular formula C8H7F3O and molecular weight 176.14 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(Difluoromethoxy)-1-fluoro-2-methylbenzene (C8H7F3O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4-(Difluoromethoxy)-1-fluoro-2-methylbenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7F3O |
| Molecular Weight | 176.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- 2-(Difluoromethoxy)-4-fluoro-1-methylbenzene (CAS 1214333-40-0)
- 1-(Difluoromethoxy)-3-fluoro-2-methylbenzene (CAS 1214333-52-4)
- 4-(Difluoromethoxy)-2-fluoro-1-methylbenzene (CAS 1214337-06-0)
- 2-(Difluoromethoxy)-1-fluoro-3-methylbenzene (CAS 1214349-66-2)
- 1-(Difluoromethoxy)-4-fluoro-2-methylbenzene (CAS 1214378-64-9)
- 2-(Difluoromethoxy)-1-fluoro-4-methylbenzene (CAS 1214382-97-4)
- 1-(Difluoromethoxy)-2-fluoro-3-methylbenzene (CAS 90370-43-7)
- 4-(Difluoromethoxy)-2-fluoroaniline (CAS 1003865-65-3)
Recommended Standards
- 5-(Difluoromethyl)-2-fluoroanisole (CAS 1214333-36-4)
- 4-(Difluoromethyl)-3-fluoroanisole (CAS 1214329-92-6)
- 2-(Difluoromethyl)-5-fluoroanisole (CAS 1214338-95-0)
- (R)-2,2,2-trifluoro-1-(pyridin-3-yl)ethan-1-amine (CAS 1212813-98-3)
- 1-[(5-Methyl-isoxazol-3-ylcarbamoyl)-methyl]-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid (CAS 1171917-11-5)
- Methyl 3-(4-(aminomethyl)tetrahydro-2H-pyran-4-yl)propanoate hydrochloride (CAS 2760521-69-3)
- (3S)-8-fLuoro-1-methyl-3-[2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-2,4(1h,3h)-quinazolinedione (CAS 1643446-65-4)
- Ac-Met-Ala-Ser-OH (CAS 149151-19-9)
- Ethyl 8-[3-(N,N-dimethylamino)phenyl]-8-oxooctanoate (CAS 951885-92-0)
- 2-Amino-3-(tetrahydro-pyran-2-ylsulfanyl)-propionic acid methyl ester, oxalate (CAS 247225-26-9)
- Methyl 2-(4-ethoxyphenyl)-2-methylpropanoate (CAS 345352-38-7)
- Dopamine Impurity 82 (CAS 5663-54-7)
- 2-(3,4-Dichlorophenyl)morpholine hydrochloride (CAS 1251033-61-0)
- Semaglutide Impurity 151 xTFA (CAS CATO-C4X-2226151)
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