Methyl 3-chloro-4,5-difluorobenzoate CAS 1214344-87-2
| CAS No. | 1214344-87-2 |
| Molecular Formula | C8H5ClF2O2 |
| Molecular Weight | 206.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Methyl 3-chloro-4,5-difluorobenzoate (CAS 1214344-87-2), molecular formula C8H5ClF2O2 and molecular weight 206.57 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Methyl 3-chloro-4,5-difluorobenzoate (C8H5ClF2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Methyl 3-chloro-4,5-difluorobenzoate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5ClF2O2 |
| Molecular Weight | 206.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Methyl Standards
- 2-(4-Chloro-3,5-difluorophenyl)acetic acid (CAS 1000566-17-5)
- 3-Chloro-alpha,alpha-difluorobenzeneacetic Acid (CAS 1027513-91-2)
- 3-Chloro-4-(difluoromethoxy)benzaldehyde (CAS 1121585-21-4)
- 2-chloro-6-(difluoromethoxy)benzaldehyde (CAS 1184404-08-7)
- Methyl 4-chloro-2,3-difluorobenzoate (CAS 1214334-98-1)
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- Methyl 5-chloro-2,3-difluorobenzoate (CAS 1214386-96-5)
- Methyl 2-chloro-3,4-difluorobenzoate (CAS 1261562-52-0)
Recommended Standards
- 2-(2-Chlorophenyl)-2,2-difluoroacetic Acid (CAS 1150164-78-5)
- 125369-56-4 2,6-Difluoro-4-methoxybenzoyl chloride DTXSID60381120 (CAS 125369-56-4)
- 2-(2-Chloro-3,4-difluorophenyl)acetic acid (CAS 1261598-59-7)
- 2-(5-Chloro-2,4-difluorophenyl)acetic acid (CAS 1261632-58-9)
- Methyl 2-(difluoromethyl)-6-oxo-1,6-dihydropyridine-3-carboxylate (CAS 1774901-13-1)
- tert-Butyl 4-(cyclopropylamino)-4-methylpiperidine-1-carboxylate (CAS 1420816-57-4)
- 2-[(4,6-Dimethyl-2-pyrimidinyl)amino]ethanol (CAS 1742-29-6)
- Ethyl 1-Boc-piperidine-2-carboxylate (CAS 362703-48-8)
- 3-(2-Methoxyphenyl)-3-oxopropanenitrile (CAS 35276-83-6)
- ((2-(Aminomethyl)benzyl)imino)dimethyl-lambda6-sulfanone (CAS 1621962-45-5)
- 2-[(2R)-pyrrolidin-2-yl]ethanol (CAS 63847-40-5)
- 2-(2-Morpholinoacetamido)benzamide (CAS 55695-73-3)
- Tert-butyl 2-amino-5,6,7,8-tetrahydro-4H-5,8-epiminocyclohepta[d]thiazole-9-carboxylate (CAS 693267-71-9)
- Polyphemusin II-Derived Peptide (CAS 229030-20-0)
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