Ethyl 4-thioxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate CAS 1216991-34-2
| CAS No. | 1216991-34-2 |
| Molecular Formula | C13H10F3NO2S |
| Molecular Weight | 301.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ethyl 4-thioxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate.
Ethyl 4-thioxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate (CAS 1216991-34-2) is a high-purity analytical reference standard with the molecular formula C13H10F3NO2S and a molecular weight of 301.28 g/mol.
Ethyl 4-thioxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate (C13H10F3NO2S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 4-thioxo-8-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H10F3NO2S |
| Molecular Weight | 301.28 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Ethyl Standards
- Ethyl 4-thioxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate (CAS 1209409-72-2)
- Ethyl 4-thioxo-6-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate (CAS 1216580-67-4)
- 6-Phenyl-2-thioxo-4-(p-tolyl)-1,2-dihydropyridine-3-carbonitrile (CAS 332126-96-2)
- 3-Ethyl-2-thioxo-7-(p-tolyl)-2,3-dihydrothieno[3,2-d]pyrimidin-4(1H)-one (CAS 1291486-91-3)
- 2-Thioxo-2,3-dihydro-1H-spiro[benzo[h]quinazoline-5,1'-cyclohexan]-4(6H)-one (CAS 250216-00-3)
- 2-(4-Oxo-2-thioxo-1,2-dihydroquinazolin-3(4H)-yl)benzoic acid (CAS 60849-65-2)
- 2-Thioxo-6-(p-tolyl)-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile (CAS 608491-88-9)
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Recommended Standards
- 8-Oxo-7-thioguanosine (CAS 122970-43-8)
- 2-(2-(4-Fluorophenyl)-4-oxopyrazolo[1,5-a]pyrazin-5(4H)-yl)-N-hydroxyacetimidamide (CAS 1255791-17-3)
- 2-((2-Methyl-7-(trifluoromethyl)quinolin-4-yl)thio)acetic acid (CAS 1208785-74-3)
- Ethyl 2-(3-(trifluoromethyl)phenyl)thiazole-4-carboxylate (CAS 132089-39-5)
- Imidodicarbonimidic acid, 1,3-dimethyl ester (CAS 25649-35-8)
- 157231-41-9 4-Benzo[g]quinoxalin-2-yl-1,2R,3S-Butanetriol [S-(R*,S*)]-4-Benzo[g]quinoxalin-2-yl-1,2,3-butanetriol (CAS 157231-41-9)
- 4-Chloro-5-ethyl-6-(methylthio)pyrimidine (CAS 1340052-38-1)
- 3'-Methoxybiphenyl-4-sulfonyl chloride (CAS 186550-26-5)
- tert-Butyl 4-(3-(3-fluorophenyl)-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate (CAS 1205638-05-6)
- 2-Amino-4-(4-fluorophenyl)butanoic acid (CAS 225233-79-4)
- (1S,3s)-3-methoxy-N-methylcyclobutan-1-amine hydrochloride (CAS 1807941-52-1)
- Potassium O-benzyl carbonodithioate (CAS 2720-79-8)
- Ethyl 4,5-dimethylfuran-2-carboxylate (CAS 119155-04-3)
- Serpent Peptide (CAS 823202-99-9)
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