(2-Ethoxy-5-(trifluoromethyl)pyridin-3-yl)boronic acid CAS 1218790-66-9
| CAS No. | 1218790-66-9 |
| Molecular Formula | C8H9BF3NO3 |
| Molecular Weight | 234.97 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(2-Ethoxy-5-(trifluoromethyl)pyridin-3-yl)boronic acid (CAS 1218790-66-9) is a high-purity analytical reference standard with the molecular formula C8H9BF3NO3 and a molecular weight of 234.97 g/mol.
The molecular framework of (2-Ethoxy-5-(trifluoromethyl)pyridin-3-yl)boronic acid (C8H9BF3NO3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9BF3NO3 |
| Molecular Weight | 234.97 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ethoxy Standards
- (6-Ethoxy-5-(trifluoromethyl)pyridin-3-yl)boronic acid (CAS 849934-85-6)
- 1-Ethoxy-2-nitro-4-(trifluoromethyl)benzene (CAS 655-08-3)
- 1-Ethoxy-4-nitro-2-(trifluoromethyl)benzene (CAS 3094-08-4)
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- 3-Ethoxy-5-(trifluoromethyl)picolinic acid (CAS 257862-54-7)
- 4-ethoxy-1-nitro-2-(trifluoromethyl)benzene (CAS 363-96-2)
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Recommended Standards
- 2,3-Dichloro-1,1,1,4,4,4-hexafluorobutane (CAS 384-54-3)
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- 2,5-Dichloro-N-(2-(methylsulfonyl)phenyl)thiophene-3-carboxamide (CAS 920354-25-2)
- (S)-2-Amino-1-(2-((benzyl(isopropyl)amino)methyl)pyrrolidin-1-yl)ethanone (CAS 1354016-93-5)
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- Semaglutide impurity 202 (CAS CATO-C4X-2226202)
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