2-(2-Fluorophenoxy)-4-methylthiazole-5-carboxylic acid CAS 1219581-80-2
| CAS No. | 1219581-80-2 |
| Molecular Formula | C11H8FNO3S |
| Molecular Weight | 253.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(2-Fluorophenoxy)-4-methylthiazole-5-carboxylic acid.
2-(2-Fluorophenoxy)-4-methylthiazole-5-carboxylic acid (CAS 1219581-80-2) is a high-purity analytical reference standard with the molecular formula C11H8FNO3S and a molecular weight of 253.25 g/mol.
The molecular framework of 2-(2-Fluorophenoxy)-4-methylthiazole-5-carboxylic acid (C11H8FNO3S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H8FNO3S |
| Molecular Weight | 253.25 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Fluorophenoxy Standards
- 2-((2-Fluorophenoxy)methyl)thiazole-4-carboxylic acid (CAS 1045283-48-4)
- 2-(4-Fluorophenoxy)-4-methylthiazole-5-carboxylic acid (CAS 1219539-96-4)
- 2-[(4-fluorophenoxy)methyl]-1,3-thiazole-4-carboxylic acid (CAS 949980-48-7)
- 1-[(2-Fluorophenoxy)acetyl]azetidine-3-carboxylic acid (CAS 1350989-09-1)
- 4-Ethyl-5-[(4-fluorophenoxy)methyl]-4H-1,2,4-triazole-3-thiol (CAS 667436-83-1)
- 5-(1-(4-Fluorophenoxy)ethyl)-4-methyl-4H-1,2,4-triazole-3-thiol (CAS 725217-86-7)
- 1-(4-Fluorophenoxy)-2-methyl-3-(pyrrolidin-1-yl)propan-2-ol (CAS 866154-77-0)
- 3-(2-Fluorophenoxy)propane-1-sulfonyl chloride (CAS 1340418-97-4)
Recommended Standards
- tert-Butyl (6-methyl-5-nitropyridin-3-yl)carbamate (CAS 1219948-26-1)
- 2-(2-Methoxyethyl)-1-oxo-1,2,3,6,7,7a-hexahydro-3a,6-epoxyisoindole-7-carboxylic acid (CAS 1212306-34-7)
- tert-Butyl (3-methyl-5-nitropyridin-2-yl)carbamate (CAS 1230637-09-8)
- N1-Boc-5-nitro-1,2-benzenediamine (CAS 1201641-95-3)
- 5-Cyclopropyl-4-fluoro-1H-pyrazole-3-carboxylic acid (CAS 681034-74-2)
- 1-(4-Isobutylphenyl)ethane-1-sulfonyl chloride (CAS 1249516-74-2)
- 3-Bromo-2,6-dichloro-4-methylpyridine (CAS 1935951-83-9)
- 5-Bromo-3-chloro-1H-pyrazolo[3,4-c]pyridine (CAS 929617-31-2)
- tert-Butyl 1H-pyrazolo[4,3-c]pyridine-3-carboxylate (CAS 2140305-56-0)
- 1-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)-3-(2-phenoxyphenyl)thiourea (CAS 326815-41-2)
- 3-(2,6-Dichlorophenyl)-5-methyl-N-[3-methyl-4-(propan-2-yl)phenyl]-1,2-oxazole-4-carboxamide (CAS 946387-21-9)
- 1-Chloro-6-isoquinolinecarboxaldehyde (CAS 1211528-19-6)
- 8-Bromo-3-butyl-1-chloro-5,10-dihydroimidazo[1,5-b]isoquinoline (CAS 1246820-05-2)
- Liraglutide Impurity 21 TFA Salt (CAS CATO-C4X-199221)
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