1-(2-Chloroacetyl)-3-piperidinecarboxylic acid CAS 1219948-48-7
| CAS No. | 1219948-48-7 |
| Molecular Formula | C8H12ClNO3 |
| Molecular Weight | 205.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(2-Chloroacetyl)-3-piperidinecarboxylic acid (CAS 1219948-48-7), molecular formula C8H12ClNO3 and molecular weight 205.64 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, 1-(2-Chloroacetyl)-3-piperidinecarboxylic acid is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 205.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H12ClNO3 |
| Molecular Weight | 205.64 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloroacetyl Standards
- 1-(2-Chloroacetyl)-2-piperidinecarboxylic acid (CAS 1236257-83-2)
- methyl 4-(2-chloroacetyl)-1H-pyrrole-2-carboxylate (CAS 1415820-00-6)
- (S)-3-(2-Chloroacetyl)-4-isopropyloxazolidin-2-one (CAS 93617-85-7)
- 1-(2-Chloroacetyl)-5-fluoropyrimidine-2,4(1H,3H)-dione (CAS 110073-43-3)
- 1-(2-Chloroacetyl)piperidine-2-carboxamide (CAS 1008495-19-9)
- 1-(2-chloroacetyl)-N-methylpyrrolidine-2-carboxamide (CAS 1247391-14-5)
- N-(1-(2-Chloroacetyl)pyrrolidin-3-yl)acetamide (CAS 1353965-56-6)
- 1-(2-Chloroacetyl)piperidine-3-carboxamide (CAS 877964-41-5)
Recommended Standards
- 5-Chloro-[2,4'-bipyridin]-3-amine (CAS 1214370-80-5)
- 6-(2-Chlorophenyl)pyrazin-2-amine (CAS 1224741-03-0)
- 2-chloro-4-(pyridin-3-yl)phenol (CAS 1214356-93-0)
- 4-chloro-2-(pyridin-3-yl)phenol (CAS 1214337-83-3)
- N-methyl-N-phenylmorpholin-3-amine (CAS 1489640-57-4)
- 5-Amino-1-ethyl-[3,4'-bipyridin]-6(1H)-one (CAS 62749-45-5)
- n-(Bicyclo[2.2.1]hept-5-en-2-ylmethyl)-1-methoxypropan-2-amine (CAS 1218643-10-7)
- 6-Chloro-7-(phenylamino)quinoline-5,8-dione (CAS 61431-04-7)
- 498-77-1 Benzethonium hydroxide N-benzyl-N,N-dimethyl-2-(2-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)ethoxy)ethanaminium (CAS 498-77-1)
- (S)-Benzyl (1-amino-3-hydroxy-1-oxopropan-2-yl)carbamate (CAS 70897-15-3)
- 6,6-Dimethyl-morpholine-3,4-dicarboxylic acid 4-benzyl ester (CAS 1255098-53-3)
- 5-Bromo-2-naphthyl 2-(6-Methoxy-2-naphthyl)propanoate (CAS 1363166-31-7)
- (4-Bromo-2,6-dimethylphenyl)methanol (CAS 17100-59-3)
- D-allo-Thr7-Semaglutide (CAS CATO-C4X-2226242)
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