3-Chloro-N-(4-fluorophenyl)-5-(trifluoromethyl)-2-pyridinamine CAS 1219976-66-5
| CAS No. | 1219976-66-5 |
| Molecular Formula | C12H7ClF4N2 |
| Molecular Weight | 290.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 290.64 g/mol gives 3-Chloro-N-(4-fluorophenyl)-5-(trifluoromethyl)-2-pyridinamine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-Chloro-N-(4-fluorophenyl)-5-(trifluoromethyl)-2-pyridinamine (CAS 1219976-66-5) is a high-purity analytical reference standard with the molecular formula C12H7ClF4N2 and a molecular weight of 290.64 g/mol.
The molecular framework of 3-Chloro-N-(4-fluorophenyl)-5-(trifluoromethyl)-2-pyridinamine (C12H7ClF4N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-Chloro-N-(4-fluorophenyl)-5-(trifluoromethyl)-2-pyridinamine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H7ClF4N2 |
| Molecular Weight | 290.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2'-Chloro-4'-(difluoromethoxy)-2,3-difluoro-1,1'-biphenyl (CAS 1261573-51-6)
- 4'-Chloro-3'-(difluoromethoxy)-2,3-difluoro-1,1'-biphenyl (CAS 1261852-58-7)
- 4-Chloro-5-methoxy-3-(2,2,2-trifluoroethoxy)thiophene-2-carboxylic acid (CAS 1779123-66-8)
- 5-Chloro-4'-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-2-ol (CAS 1928702-91-3)
- 2-Chloro-5-methoxyphenyl trifluoromethanesulfonate (CAS 193353-36-5)
- 5-Chloro-4-fluoro-3'-(trifluoromethyl)-[1,1'-biphenyl]-2-ol (CAS 1963448-86-3)
- 5-Chloro-1-phenyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid (CAS 1152972-16-1)
- 5-Chloro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazole-3-carboxylic acid (CAS 1355224-27-9)
Recommended Standards
- 2-Methoxy-5-(trifluoromethoxy)benzenesulfonyl chloride (CAS 1010422-55-5)
- 2-methoxy-6-(trifluoromethoxy)benzene-1-sulfonyl chloride (CAS 1261457-38-8)
- 4-Amino-1-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)pyrimidin-2(1H)-one (CAS 338420-22-7)
- 3-(4-Chlorophenyl)-6-(trifluoromethyl)pyrimidine-2,4(1H,3H)-dione (CAS 37836-64-9)
- 2,4-Bis(trifluoromethyl)-6-bromophenol (CAS 1414870-83-9)
- 2-(((4-(4,5-Dichloro-1H-imidazol-1-yl)phenyl)imino)methyl)-3-hydroxy-1H-inden-1-one (CAS 1024316-38-8)
- 1-benzylpyrrolidin-2-one 2-pyrrolidinone, 1-(phenylmethyl)- 5291-77-0 InChI=1/C11H13NO/c13-11-7-4-8-12(11)9-10-5-2-1-3-6-10/h1-3,5-6H,4,7-9H (CAS 5291-77-0)
- 4-Chloro-6-propylpyrimidine (CAS 141602-33-7)
- 2-(4-(2-Chloroacetyl)phenyl)acetonitrile (CAS 55844-34-3)
- 2,3-Difluorostyrene (CAS 1080636-91-4)
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- Methyl 3,5-dihydroxycyclohexane-1-carboxylate (CAS 1443770-02-2)
- 5-Methyl-3-phenylpyridin-2(1H)-one (CAS 53428-05-0)
- Gastric Inhibitory Polypeptide (6-30) amide (human) (CAS 1139691-72-7)
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