Phenoxymethylpenicillin EP Impurity B CAS 122-59-8
| CAS No. | 122-59-8 |
| Molecular Formula | C8H8O3 |
| Molecular Weight | 152.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Phenoxymethylpenicillin EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Phenoxymethylpenicillin EP Impurity B (CAS 122-59-8), a pharmacopoeial impurity reference standard (molecular formula C8H8O3, MW 152.15 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Phenoxymethylpenicillin EP Impurity B (C8H8O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 152.15 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H8O3 |
| Molecular Weight | 152.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Phenoxymethylpenicillin Standards
- Phenoxymethylpenicillin Impurity 24 (CAS 1620319-31-4)
- Phenoxymethylpenicillin Calcium - API Standards (CAS 147-48-8)
- Phenoxymethylpenicillin EP Impurity E HCl（Penicilloic acids of phenoxymethylpenicillin） (CAS 1049-84-9 (free base))
- Phenoxymethylpenicillin EP Impurity F (2R,4S) (CAS 196701-54-9)
- Phenoxymethylpenicillin EP Impurity F (CAS 2714805-53-3)
- Phenoxymethylpenicillin EP Impurity F（SS） (CAS CATO-C4X-21269)
- Phenoxymethylpenicillin Impurity 23 (CAS CATO-C4X-212623)
- Phenoxymethylpenicillin EP Impurity D (CAS 20880-67-5)
Recommended Standards
- Neostigmine impurity 32 (CAS 23040-64-4)
- Nifuroxazide EP Impurity A (CAS 5351-23-5)
- Nicotine Impurity 21 (CAS 769-49-3)
- N-Nitroso Compounds 33 (CAS 28571-11-1)
- Ofloxacin Impurity 10 (CAS 107884-32-2)
- Neomycin EP Impurity F (CAS 51795-47-2)
- Miglitol Impurity 19 (CAS 78614-47-8)
- 2-(4-Methylpiperazin-1-yl)-5-nitrobenzonitrile (CAS 451459-92-0)
- 2-(2,3-Dichlorophenyl)-5-hydroxypyridine (CAS 1261910-43-3)
- Methyl 1-(2,6-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxylate (CAS 338783-07-6)
- N-[9-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenyl-methoxy]methyl]-4-[2-cyanoethoxy-(diisopropylamino)phosphanyl]oxy-tetrahydrofuran-2-yl]-8-hydroxy-6-oxo-5H-purin-2-yl]-2-methyl-propanamide (CAS 143060-53-1)
- 5-(4-(tert-Butoxycarbonyl)piperazin-1-yl)pyrazine-2-carboxylic acid (CAS 1209646-17-2)
- ((Diethoxyphosphoryl)(tosyloxy)methyl)phosphonic acid (CAS CATO-C3D-262219)
- HA Peptide (CAS 92000-76-5)
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