4-[(2,6-Difluorobenzyl)oxy]piperidinehydrochloride CAS 1220035-52-8
| CAS No. | 1220035-52-8 |
| Molecular Formula | C12H15F2NO |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-[(2,6-Difluorobenzyl)oxy]piperidinehydrochloride.
4-[(2,6-Difluorobenzyl)oxy]piperidinehydrochloride (CAS 1220035-52-8) is a high-purity analytical reference standard with the molecular formula C12H15F2NOHCl and a molecular weight of 263.71 g/mol.
4-[(2,6-Difluorobenzyl)oxy]piperidinehydrochloride (C12H15F2NOHCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-[(2,6-Difluorobenzyl)oxy]piperidinehydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H15F2NO HCl |
| Molecular Weight | 263.71 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Difluorobenzyl Standards
- (R)-1-(3,4-Difluorobenzyl)-2-oxo-N-(2-((2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)oxy)-1-phenylethyl)-1,2-dihydropyridine-3-carboxamide (CAS 1001409-50-2)
- Ethyl 1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylate (CAS 1001412-63-0)
- 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic Acid (CAS 1001413-01-9)
- 1-(3,4-Difluorobenzyl)-2-oxo-N-(thiophen-2-ylmethyl)-1,2-dihydropyridine-3-carboxamide (CAS 1001413-87-1)
- Methyl 1-(3,4-difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylate (CAS 1001414-50-1)
- n-(3,5-Difluorobenzyl)-1-(1-methyl-1h-pyrazol-4-yl)methanamine (CAS 1006436-32-3)
- N-(3,5-difluorobenzyl)-1-(1,3-dimethyl-1H-pyrazol-4-yl)methanamine (CAS 1006436-76-5)
- n-(2,5-Difluorobenzyl)-1-(1,3-dimethyl-1h-pyrazol-4-yl)methanamine (CAS 1006449-75-7)
Recommended Standards
- Hexacene, Technical Grade (CAS 258-31-1)
- Allylchloro[1,3-bis(2,6-di-i-propylphenyl)imidazol-2-ylidene]palladium(II) 478980-03-9 (NHC)PD(ALLYL)CL;ALLYLCHLORO[1,3-BIS(2,6-DI-I-PROPYLPHENYL)IMIDAZOL-2-YLIDENE]PALLADIUM(II);ALLYLCHLORO[1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOL-2-YLIDENE]PALLADIUM(II);ALLYLCHLORO[1,3-BIS(DIISOPROPYLPHENYL)IMIDAZOLE-2-YLIDENE]PALLADIUM(II);ALLYL[1,3-BIS(2,6-DIISOPROPYLPHENYL)IMIDAZOL-2-YLIDENE]CHLOROPALLADIUM(II);CX 21;UMICORE CX21 SC10492 (CAS 478980-03-9)
- (S)-1-(5-bromo-2-fluorophenyl)ethan-1-amine hydrochloride (CAS 1228565-59-0)
- 2-(3-Methoxy-4-methylisoxazol-5-yl)ethanol (CAS 157170-95-1)
- 1-(3-Chlorobenzyl)-3-(2-cyano-4,5-dimethoxyphenyl)thiourea (CAS 343375-04-2)
- 2-(2-Cyano-3-(difluoromethyl)-5-fluoropyridin-4-yl)acetic acid (CAS 1805920-00-6)
- 2-Pyridinamine, 3-(dimethylphosphinyl)-5-[(4-methoxyphenyl)methoxy]- (CAS 2886000-55-9)
- N-(4-chlorobenzyl)-6-(1H-pyrazol-1-yl)nicotinamide (CAS 321533-72-6)
- N-Desethyl Amodiaquine-d5 (CAS 1173023-19-2)
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