Trans-3,4-bis(3,4-dimethoxybenzyl)tetrahydrofuran CAS 122045-63-0

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Trans-3,4-bis(3,4-dimethoxybenzyl)tetrahydrofuran.

Trans-3,4-bis(3,4-dimethoxybenzyl)tetrahydrofuran (CAS 122045-63-0), molecular formula C22H28O5 and molecular weight 372.45 g/mol, is a CATO reference standard with documented purity and traceability.

Owing to a flavonoid core, a hydroxyl group, an ether linkage, Trans-3,4-bis(3,4-dimethoxybenzyl)tetrahydrofuran is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 372.45 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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