5-(Chloromethyl)-1-phenyl-1H-1,2,4-triazole-3-carboxylic acid CAS 1221792-24-0
| CAS No. | 1221792-24-0 |
| Molecular Formula | C10H8ClN3O2 |
| Molecular Weight | 237.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 5-(Chloromethyl)-1-phenyl-1H-1,2,4-triazole-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies 5-(Chloromethyl)-1-phenyl-1H-1,2,4-triazole-3-carboxylic acid (CAS 1221792-24-0), a certified reference material (molecular formula C10H8ClN3O2, MW 237.64 g/mol) for analytical method development and quality control.
5-(Chloromethyl)-1-phenyl-1H-1,2,4-triazole-3-carboxylic acid (C10H8ClN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C10H8ClN3O2 |
| Molecular Weight | 237.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloromethyl Standards
- 3-(Chloromethyl)-4-(4-hydroxybenzylidene)isoxazol-5(4H)-one (CAS 1142199-72-1)
- 2-(Chloromethyl)benzo[d]oxazole-7-acrylic acid (CAS 1803424-90-9)
- 3-(4-(Chloromethyl)benzo[d]oxazol-2-yl)acrylic acid (CAS 1803424-93-2)
- 2-(Chloromethyl)benzo[d]oxazole-5-acrylic acid (CAS 1803425-77-5)
- 2-(Chloromethyl)benzo[d]oxazole-6-acrylic acid (CAS 1803426-36-9)
- 2-(Chloromethyl)-4-(difluoromethyl)-3,6-dimethoxypyridine (CAS 1805325-11-4)
- 2-(Chloromethyl)-5-(difluoromethyl)-3,6-dimethoxypyridine (CAS 1806821-33-9)
- 2-(Chloromethyl)-3,5-Dimethyl-4-(2,2,2-Trifluoroethyl)Pyridine (CAS 256642-27-0)
Recommended Standards
- 2-(5-(4-Chlorophenyl)-4H-1,2,4-triazol-3-yl)acetic acid (CAS 1203243-07-5)
- 7-Chloro-2-hydroxy-6-methoxyquinoline-3-carbaldehyde (CAS 1225335-03-4)
- 1-(2-Chloro-4-nitrophenyl)-4-methyl-1h-pyrazole (CAS 1174886-67-9)
- (2-chloro-3-formyl-1H-indol-5-yl) acetate (CAS 1233354-97-6)
- (6-Fluoroimidazo[1,2-a]pyridin-2-yl)methanol (CAS 1038827-63-2)
- n-(Benzo[d][1,3]dioxol-4-ylmethyl)-2-(1h-pyrazol-1-yl)ethan-1-amine (CAS 1291625-08-5)
- 2,3-dihydro-1H-indole-1-sulfonamide (CAS 34917-77-6)
- (R)-2,2-Difluorocyclobutane-1-carboxylic acid (CAS 2742942-02-3)
- 1-(5-Fluoro-2-(isopentyloxy)phenyl)propan-1-one (CAS 1443345-68-3)
- 1-(6-Aminoindolin-1-yl)ethan-1-one (CAS 62368-29-0)
- N-[1-(5-Carbamoyladamantan-2-ylamino)-1-oxo-2-methyl-2-propanyl]-2-fluorobenzenesulfonamid (CAS 1422025-27-1)
- Diethyl 2,4-diacetyl-3-phenylpentanedioate (CAS 13277-74-2)
- Ethyl 5-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)isoxazole-3-carboxylate (CAS 925007-02-9)
- Hexapeptide-11 (CAS 100684-36-4)
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