(S)-1-(2,5-difluorobenzyl)piperidin-3-amine CAS 1222712-84-6
| CAS No. | 1222712-84-6 |
| Molecular Formula | C12H16F2N2 |
| Molecular Weight | 226.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies (S)-1-(2,5-difluorobenzyl)piperidin-3-amine (CAS 1222712-84-6), a certified reference material (molecular formula C12H16F2N2, MW 226.27 g/mol) for analytical method development and quality control.
The molecular framework of (S)-1-(2,5-difluorobenzyl)piperidin-3-amine (C12H16F2N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), (S)-1-(2,5-difluorobenzyl)piperidin-3-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H16F2N2 |
| Molecular Weight | 226.27 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related S Standards
- (R)-1-(2,3-difluorobenzyl)piperidin-3-amine (CAS 1222711-85-4)
- (R)-1-(2,5-difluorobenzyl)piperidin-3-amine (CAS 1222711-96-7)
- (S)-1-(2,3-difluorobenzyl)piperidin-3-amine (CAS 1222713-00-9)
- N-(3,4-difluorobenzyl)-N-methylpyrrolidin-3-amine (CAS 1343062-29-2)
- 1-(3,5-Difluorobenzyl)piperidin-3-amine (CAS 1536837-98-5)
- 1-(3,5-Difluorobenzyl)-1,3-dihydro-2H-imidazole-2-thione (CAS 95333-81-6)
- 5-(3,4-difluorobenzyl)-1,3-thiazol-2-amine (CAS 937617-31-7)
- 5-(3,5-Difluorobenzyl)thiazol-2(3h)-imine (CAS 926247-32-7)
Recommended Standards
- 3',4'-Dimethyl-[1,1'-biphenyl]-4-carboxylic acid (CAS 122294-09-1)
- tert-Butyl 3-cyano-3-hydroxypiperidine-1-carboxylate (CAS 1219832-34-4)
- n-(Sec-butyl)-3-(2,5-dioxopyrrolidin-1-yl)propanamide (CAS 1223028-20-3)
- 1-Bromononane-d19 (CAS 1219805-90-9)
- 1-[2-(Methylsulfonyl)ethyl]-6-oxo-1,6-dihydropyridine-3-boronic Acid Pinacol Ester (CAS 1083168-89-1)
- 3-(1-Ethylpiperidin-4-yl)-1H-indole (CAS 1892895-44-1)
- 3,5-Diethyl-(2,4-or 2,6-)toluenediamine (CAS 75389-89-8)
- 5-Hydroxyomeprazole Sulfone (CAS 151602-51-6)
- 2-(4-(Difluoromethyl)-5-hydroxy-6-iodopyridin-3-yl)acetonitrile (CAS 1805535-09-4)
- 5-(3-(Methylsulfonyl)phenyl)oxazol-2-amine (CAS 2092686-13-8)
- n-Phenyl-5,6-dihydro-4h-cyclopenta[b]thiophene-2-carboxamide (CAS 950025-59-9)
- o-(2,4-Dinitrobenzyl)hydroxylamine (CAS 1542442-38-5)
- 3-Ethyl-1-phenylpyrrolidine-2,5-dione (CAS 588672-40-6)
- Semaglutide Impurity 192 (CAS CATO-C4X-2226192)
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