4-Chloro-6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)pyrimidin-2-amine CAS 1223591-33-0
| CAS No. | 1223591-33-0 |
| Molecular Formula | C11H15ClN4O2 |
| Molecular Weight | 270.72 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)pyrimidin-2-amine.
CATO supplies 4-Chloro-6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)pyrimidin-2-amine (CAS 1223591-33-0), a certified reference material (molecular formula C11H15ClN4O2, MW 270.72 g/mol) for analytical method development and quality control.
Structurally, 4-Chloro-6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)pyrimidin-2-amine (C11H15ClN4O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 270.72 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4-Chloro-6-(1,4-dioxa-8-azaspiro[4.5]decan-8-yl)pyrimidin-2-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H15ClN4O2 |
| Molecular Weight | 270.72 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- 4-Chloro-6-(4-(2-hydroxyethyl)piperazin-1-yl)pyrimidine-5-carbaldehyde (CAS 1427460-95-4)
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Recommended Standards
- Tert-butyl 2-amino-4-chloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate (CAS 1207175-28-7)
- 2-(1-Benzyl-1H-pyrazol-4-yl)-4-chloropyrimidine (CAS 1365957-51-2)
- 2-Amino-1-(3-chloro-4-cyanophenyl)-4,5-dimethyl-1H-pyrrole-3-carbonitrile (CAS 1094743-20-0)
- 3-(5-(4-Chlorophenyl)-1H-1,2,4-triazol-3-yl)aniline (CAS 1092305-79-7)
- tert-Butyl (2S,4R)-4-(tert-butoxy)-2-formylpyrrolidine-1-carboxylate (CAS 2348282-31-3)
- 2-(3-Fluoro-4-methylphenyl)butan-2-ol (CAS 1379326-05-2)
- (6-Isobutoxypyrimidin-4-yl)methanamine (CAS 1439900-26-1)
- N-[7-methoxy-8-(3-morpholin-4-ylpropoxy)-2,3-dihydro-1H-imidazo[1,2-c]quinazolin-5-ylidene]formamide (CAS 1219637-58-7)
- 5-Methanesulfonyl-1-methyl-1H-indole-3-carboxylic acid (CAS 1555336-67-8)
- (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-methylbut-3-ynoic acid (CAS 1217662-67-3)
- 4-(Methoxymethyl)-6-methyl-5-nitro-1H-pyrazolo[3,4-b]pyridin-3-amine (CAS 59225-09-1)
- 2-[4-(6-Chloro-2-pyrazinyl)-1-piperazinyl]-1-ethanol (CAS 1219981-14-2)
- (2-(1-(4,5-Dihydro-1H-imidazol-2-yl)-2-phenylethyl)phenyl)boronic acid (CAS 65734-27-2)
- Des-Pro36-Tirzepatide (CAS CATO-CPTD788937)
Why CATO?
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