Sodium Iothalamate CAS 1225-20-3
| CAS No. | 1225-20-3 |
| Molecular Formula | C11H8I3N2O4 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Sodium Iothalamate.
Sodium Iothalamate (CAS 1225-20-3), molecular formula C11H8I3N2O4Na and molecular weight 635.88 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Sodium Iothalamate (C11H8I3N2O4Na) is characterized by a salt form, a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Sodium Iothalamate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H8I3N2O4 Na |
| Molecular Weight | 635.88 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
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- 3-Amino-3-(5-chlorothiophen-2-yl)propanamide (CAS 771530-00-8)
- 1-(Tert-butyl)-3-phenylthiourea (CAS 14327-04-9)
- 4,6-Dichloro-1-(1,4-dioxaspiro[4.5]decan-8-yl)-1H-pyrazolo[3,4-d]pyrimidine (CAS 1144080-31-8)
- 1-Methyldibenzofuran (CAS 7320-50-5)
- 4-(Pyridin-4-yloxy)benzoic acid hydrochloride (CAS 1306606-31-4)
- 4-Bromo-1-methyl-2-(pentyloxy)benzene (CAS 1309932-69-1)
- Methyl (1s,3s)-3-(methylamino)cyclobutane-1-carboxylate (CAS 1989638-35-8)
- Neuropeptide Y (2-36) (human, rat) trifluoroacetate salt (CAS 123139-39-9)
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