1-(Difluoromethoxy)-3-(1-methylethyl)benzene CAS 1225522-34-8
| CAS No. | 1225522-34-8 |
| Molecular Formula | C10H12F2O |
| Molecular Weight | 186.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(Difluoromethoxy)-3-(1-methylethyl)benzene (CAS 1225522-34-8) is a high-purity analytical reference standard with the molecular formula C10H12F2O and a molecular weight of 186.20 g/mol.
Based on its molecular formula C10H12F2O, 1-(Difluoromethoxy)-3-(1-methylethyl)benzene contains a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 186.20 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12F2O |
| Molecular Weight | 186.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
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Recommended Standards
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- 4-(3,4-Difluorophenyl)butan-1-ol (CAS 1215948-69-8)
- 1-(3,5-Difluorophenyl)butan-1-ol (CAS 1226165-53-2)
- methyl 2-amino-5-pentyl-thiophene-3-carboxylate (CAS 791602-18-1)
- Pyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (CAS 21038-66-4)
- N-(3-Aminophenyl)-2-[2-(tert-butyl)phenoxy]-acetamide (CAS 954564-13-7)
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- 2-methyl-4H-pyrazolo[1,5-a]pyrimidin-5-one (CAS 189116-35-6)
- 2-Amino-2-(pyrrolidin-3-yl)acetic acid (CAS 1214812-00-6)
- 2-(Chlorosulfonyl)ethyl acetate (CAS 78303-71-6)
- 9,10-Dimethylanthracene-2,3,6,7-tetraol (CAS 13979-56-1)
- 5-(4-Methoxyphenyl)-2-(thiophen-2-yl)-1H-imidazole, 97% (CAS 102152-10-3)
- Tirzepatide Impurity 9 (CAS CATO-C4X-32409)
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