5-(3-Methoxyphenyl)-1H-pyrrole-2-carboxylic acid CAS 1225551-48-3
| CAS No. | 1225551-48-3 |
| Molecular Formula | C12H11NO3 |
| Molecular Weight | 217.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(3-Methoxyphenyl)-1H-pyrrole-2-carboxylic acid.
5-(3-Methoxyphenyl)-1H-pyrrole-2-carboxylic acid (CAS 1225551-48-3) is a high-purity analytical reference standard with the molecular formula C12H11NO3 and a molecular weight of 217.22 g/mol.
The molecular framework of 5-(3-Methoxyphenyl)-1H-pyrrole-2-carboxylic acid (C12H11NO3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(3-Methoxyphenyl)-1H-pyrrole-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H11NO3 |
| Molecular Weight | 217.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 1 |
Related Methoxyphenyl Standards
- 4-(2-Methoxyphenyl)-1h-pyrrole-3-carboxylic acid (CAS 1096308-15-4)
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- 4-(4-Methoxyphenyl)-1h-pyrrole-2-carboxylic acid (CAS 1204297-39-1)
- 1-[(2-methoxyphenyl)methyl]-2,5-dihydro-1H-pyrrole-2,5-dione (CAS 133137-34-5)
- 3-(4-Methoxyphenyl)-1H-pyrazole-5-carboxamide, 97% (CAS 1397191-27-3)
- 1-(4-Methoxyphenyl)-1H-imidazole-4-carboxamide (CAS 1427021-23-5)
- 5-(4-Methoxyphenyl)-1h-pyrrole-2-carboxylic acid (CAS 149769-78-8)
- 1-(3-Methoxyphenyl)-1H-pyrrole-2-carboxylic acid (CAS 188953-78-8)
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