3-(2-Chlorophenyl)picolinic acid CAS 1226215-66-2
| CAS No. | 1226215-66-2 |
| Molecular Formula | C12H8ClNO2 |
| Molecular Weight | 233.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 233.65 g/mol gives 3-(2-Chlorophenyl)picolinic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-(2-Chlorophenyl)picolinic acid (CAS 1226215-66-2) is a high-purity analytical reference standard with the molecular formula C12H8ClNO2 and a molecular weight of 233.65 g/mol.
The molecular framework of 3-(2-Chlorophenyl)picolinic acid (C12H8ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 3-(2-Chlorophenyl)picolinic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8ClNO2 |
| Molecular Weight | 233.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chlorophenyl Standards
- 2-(4-Chlorophenyl)nicotinic acid (CAS 101419-79-8)
- 4-(3-Chlorophenyl)picolinic acid (CAS 1207725-34-5)
- 2-(3-Chlorophenyl)isonicotinic acid (CAS 1207725-71-0)
- 5-(2-Chlorophenyl)picolinic acid (CAS 1221403-88-8)
- 3-(3-Chlorophenyl)picolinic acid (CAS 1225514-91-9)
- 2-(2-Chlorophenyl)isonicotinic acid (CAS 1225547-10-3)
- 5-(3-Chlorophenyl)picolinic acid (CAS 1225547-21-6)
- 2-(2-Chlorophenyl)nicotinic acid (CAS 1226215-53-7)
Recommended Standards
- 2-(3-Chlorophenyl)nicotinic acid (CAS 1226215-76-4)
- 3-(4-Chlorophenyl)picolinic acid (CAS 1226215-87-7)
- 5-(3-Chloro-4-methoxyphenyl)furan-2-carbonitrile (CAS 124014-02-4)
- 2-Amino-1-(4-chlorophenyl)-5-oxo-4,5-dihydro-1H-pyrrole-3-carbonitrile (CAS 124476-80-8)
- 2-amino-4-hydroxy-thiophene-3-carbonitrile (CAS 99580-50-4)
- 4,6-Dichloro-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrrolo[2,3-b]pyridine (CAS 881902-80-3)
- N1-(2-Chlorophenyl)-N2-((3-methoxytetrahydrothiophen-3-yl)methyl)oxalamide (CAS 1448136-97-7)
- 5-Bromo-6-fluoro-3-hydroxyindolin-2-one (CAS 1247853-48-0)
- Ethyl 5-hydroxy-4-oxo-4H-pyran-2-carboxylate (CAS 50671-51-7)
- Ethyl 5-chloro-4-methyl-2-nitrobenzoate (CAS 1805129-59-2)
- 4-[(Ethylamino)sulfonyl]benzoic Acid (CAS 10252-64-9)
- 5-(Trifluoromethyl)-2-(3-(trifluoromethyl)-3H-diazirin-3-yl)pyridine (CAS 2231674-05-6)
- n-(4-Nitrobenzyl)ethanamine (CAS 17847-35-7)
- Crustacean Cardioactive Peptide (CAS 107090-96-0)
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