3-chloro-2-fluoro-4-(trifluoromethyl)pyridine CAS 1227496-80-1
| CAS No. | 1227496-80-1 |
| Molecular Formula | C6H8ClF4N |
| Molecular Weight | 205.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-chloro-2-fluoro-4-(trifluoromethyl)pyridine (C6H8ClF4N) contains fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
3-chloro-2-fluoro-4-(trifluoromethyl)pyridine (CAS 1227496-80-1) is a high-purity analytical reference standard with the molecular formula C6H8ClF4N and a molecular weight of 205.58 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-chloro-2-fluoro-4-(trifluoromethyl)pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H8ClF4N |
| Molecular Weight | 205.58 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related chloro Standards
- 5-Chloro-6-(1,1-difluoroethyl)nicotinaldehyde (CAS 1429182-80-8)
- 4-Chloro-6-(difluoromethyl)-2-methylnicotinaldehyde (CAS 1805178-02-2)
- 2-Chloro-3-(difluoromethyl)-5-methylisonicotinaldehyde (CAS 1806033-27-1)
- 2-Chloro-5-(difluoromethyl)-3-methylisonicotinaldehyde (CAS 1806033-34-0)
- 2-Chloro-6-(difluoromethyl)-3-methylisonicotinaldehyde (CAS 1806033-38-4)
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- (E)-4-((((4-chlorobenzyl)oxy)imino)methyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carbonitrile (CAS 338415-14-8)
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- 4-Bromo-2,3-difluorobenzenesulfonyl chloride (CAS 1133123-00-8)
- Ethyl 1-(5-((4-chlorophenyl)sulfonyl)-4-phenylthiazol-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (CAS 957038-44-7)
- 4-fluorobenzyl isocyanate (CAS 132740-43-3)
- [(3,4-Dichlorophenyl)methyl](propyl)amine (CAS 90390-20-8)
- 3-(2,6-Dichlorophenyl)-4-(5-ethoxy-1,3-oxazol-2-yl)-5-methyl-1,2-oxazole (CAS 338391-67-6)
- 2-Bromo-5-chloro-3-(difluoromethyl)pyridin-4-amine (CAS 1805337-31-8)
- Neuropeptide W-23 (rat) (CAS 383415-89-2)
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