2,4-Difluoro-3-(trifluoromethyl)pyridine CAS 1227564-69-3
| CAS No. | 1227564-69-3 |
| Molecular Formula | C6H2F5N |
| Molecular Weight | 183.08 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2,4-Difluoro-3-(trifluoromethyl)pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2,4-Difluoro-3-(trifluoromethyl)pyridine (CAS 1227564-69-3) is a high-purity analytical reference standard with the molecular formula C6H2F5N and a molecular weight of 183.08 g/mol.
Based on its molecular formula C6H2F5N, 2,4-Difluoro-3-(trifluoromethyl)pyridine contains a nitrile group, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 183.08 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C6H2F5N |
| Molecular Weight | 183.08 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoro Standards
- 3,6-Difluoro-2-(trifluoromethyl)pyridine (CAS 1099597-92-8)
- 3,5-Difluoro-2-(trifluoromethyl)pyridine (CAS 1099598-21-6)
- 2,3-Difluoro-6-(trifluoromethyl)pyridine (CAS 1159512-37-4)
- 2,5-Difluoro-3-(trifluoromethyl)pyridine (CAS 1214342-94-5)
- 2,3-Difluoro-4-(trifluoromethyl)pyridine (CAS 1215034-77-7)
- 2,4-Difluoro-6-(trifluoromethyl)pyridine (CAS 1227574-57-3)
- 2,4-Difluoro-5-(trifluoromethyl)pyridine (CAS 1227587-92-9)
- 3,4-Difluoro-2-(trifluoromethyl)pyridine (CAS 1227599-07-6)
Recommended Standards
- 4-Chloroheptanoyl Chloride (CAS 111680-87-6)
- 2,5-Difluoro-4-(trifluoromethyl)pyridine (CAS 1349716-18-2)
- 2,6-Difluoro-4-(trifluoromethyl)pyridine (CAS 1378824-94-2)
- 3,5-Difluoro-4-(trifluoromethyl)pyridine (CAS 1391033-20-7)
- 1’-Methylspiro[indoline-3,4’-piperidine] (CAS 69584-91-4)
- 2,2,2-Trifluoro-1-(4-(methylthio)phenyl)ethan-1-ol (CAS 122035-81-8)
- 4-(1-Ethyl-1h-1,2,4-triazol-5-yl)-1,2,5-oxadiazol-3-amine (CAS 1344250-39-0)
- 2-(Piperidin-1-yl)-1H-benzo[d]imidazol-5-amine (CAS 832102-60-0)
- 3-Methoxy-N-(4-methylpiperidin-3-yl)propanamide (CAS 1832043-55-6)
- 2-(2-methanesulfonylethanesulfonyl)benzoic acid (CAS 1183920-59-3)
- 4-Methoxybutyl acetate (CAS 15057-11-1)
- N1-cyclopentyl-N1-(furan-2-ylmethyl)propane-1,3-diamine (CAS 835891-09-3)
- Allopurinol Impurity 9 (CAS 41621-10-7)
- Semaglutide impurity 199 (CAS CATO-C4X-2226199)
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