3-Bromo-2-((tert-butyldimethylsilyloxy)-methyl)-6-fluoroaniline CAS 1227958-00-0

Description

The occurrence of 3-Bromo-2-((tert-butyldimethylsilyloxy)-methyl)-6-fluoroaniline is closely related to an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

3-Bromo-2-((tert-butyldimethylsilyloxy)-methyl)-6-fluoroaniline (CAS 1227958-00-0) is a high-purity analytical reference standard with the molecular formula C13H21BrFNOSi and a molecular weight of 334.30 g/mol.

The molecular framework of 3-Bromo-2-((tert-butyldimethylsilyloxy)-methyl)-6-fluoroaniline (C13H21BrFNOSi) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 3-Bromo-2-((tert-butyldimethylsilyloxy)-methyl)-6-fluoroaniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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