5-Bromo-2-chloro-6-phenylnicotinonitrile CAS 1228182-75-9
| CAS No. | 1228182-75-9 |
| Molecular Formula | C12H6BrClN2 |
| Molecular Weight | 293.55 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Structurally, 5-Bromo-2-chloro-6-phenylnicotinonitrile (C12H6BrClN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 293.55 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies 5-Bromo-2-chloro-6-phenylnicotinonitrile (CAS 1228182-75-9), a certified reference material (molecular formula C12H6BrClN2, MW 293.55 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H6BrClN2 |
| Molecular Weight | 293.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
- 5-Bromo-4-chloro-6-morpholinopyrimidin-2-amine (CAS 1266380-21-5)
- 5-Bromo-6-chloro-2-phenylnicotinonitrile (CAS 1708401-31-3)
- 1-Bromo-4-nitro-2,5-bis-(trifluoromethyl)benzene (CAS 887268-05-5)
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Recommended Standards
- 4-(4-Bromophenyl)-2-chloronicotinonitrile (CAS 1225658-71-8)
- Chlorbromuron (CAS 13360-45-7)
- 5-Chloro-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole (CAS 1361380-49-5)
- 51069-90-0 6-bromo-4-chloro-2-oxo-2h-chromene-3-carbaldehyde (CAS 51069-90-0)
- N-Ethyl-N,1-dimethyl-1H-indole-2-carboxamide (CAS 815575-77-0)
- 2-(1-(Isopropylamino)ethyl)-4-methoxyphenol (CAS 1019498-61-3)
- 3-((3-Chloro-4-fluorophenyl)sulfonyl)-7-(diethylamino)-2H-chromen-2-one (CAS 904438-94-4)
- N-nitroso Pantoprazole EP Impurity E (CAS CATO-C4X-139961)
- 2-(trifluoromethyl)-1,3-benzothiazole-6-carbonitrile (CAS 1225041-14-4)
- 2-Amino-2-(1H-tetrazol-5-yl)ethanol (CAS 1403765-05-8)
- 3-Chloro-7-(dimethylamino)quinoline-8-carbonitrile (CAS 88347-00-6)
- 4-(Phenyldiazenyl)benzyl carbonochloridate (CAS 55592-99-9)
- 4-(2-Ethylbutanoyl)-N-(4-fluorobenzyl)-1H-pyrrole-2-carboxamide (CAS 478259-87-9)
- Exenatide (CAS 141758-74-9（free base）)
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