4-(4-fluorophenyl)-2-(piperidin-4-yl)pyrimidine dihydrochloride CAS 1228457-21-3
| CAS No. | 1228457-21-3 |
| Molecular Formula | C15H16FN3 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(4-fluorophenyl)-2-(piperidin-4-yl)pyrimidine dihydrochloride (C15H16FN3HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
4-(4-fluorophenyl)-2-(piperidin-4-yl)pyrimidine dihydrochloride (CAS 1228457-21-3) is a high-purity analytical reference standard with the molecular formula C15H16FN3HCl and a molecular weight of 293.77 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 4-(4-fluorophenyl)-2-(piperidin-4-yl)pyrimidine dihydrochloride under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H16FN3 2*HCl |
| Molecular Weight | 293.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related fluorophenyl Standards
- 3-[(3-fluorophenyl)methyl]pyrrolidine (CAS 1000198-80-0)
- 3-(3-Fluorophenyl)-3-oxopropanoic acid (CAS 1000530-96-0)
- Ethyl 1-(4-fluorophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate (CAS 1000573-68-1)
- 1000574-26-4 2-(4-Fluorophenyl)-6-methylthio-4H-thiopyran-4-one MFCD09877819 (CAS 1000574-26-4)
- Ethyl 1-(2-fluorophenyl)-5-oxo-2,5-dihydro-1H-1,2,4-triazole-3-carboxylate (CAS 1000575-18-7)
- 100074-04-2 5-(4-Fluorophenyl)-1-pentene MFCD11553774 (CAS 100074-04-2)
- 3-(2-Fluorophenyl)-4-hydroxyfuran-2(5H)-one (CAS 100074-44-0)
- N-[2-(4-fluorophenyl)ethyl]-1H-imidazole-1-carboxamide (CAS 1000931-75-8)
Recommended Standards
- 6-(Aminomethyl)-5-chloropyrimidine-2,4(1H,3H)-dione (CAS 183205-17-6)
- (R)-2-(2-bromo-4-fluorophenyl)pyrrolidine (CAS 1228548-34-2)
- 1-(5-Bromo-3-fluoro-2-nitrophenyl)ethan-1-one (CAS 1805555-86-5)
- 2-((5-Fluoropyridin-2-yl)oxy)acetic acid (CAS 2070-42-0)
- tert-Butyl cis-4-(N-methoxy-N-methylcarbamoyl)-cyclohexylcarbamate (CAS 304873-79-8)
- 4-Chloro-3-methylbenzene-1-sulfonyl chloride (CAS 6291-02-7)
- 3-Hydroxy-2-methylisonicotinonitrile (CAS 13602-91-0)
- 3-(Hydroxymethyl)-2,2,5,5-tetramethylpyrrolidin-1-ol (CAS 27298-75-5)
- 1287217-80-4 3-(2-Fluorophenyl)oxirane-2-carboxylic acid (CAS 1287217-80-4)
- Liraglutide Impurity 14 TFA Salt (CAS CATO-C4X-199214)
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