(1S)-1-(3-chloro-2-fluorophenyl)ethan-1-amine CAS 1228561-56-5
| CAS No. | 1228561-56-5 |
| Molecular Formula | C8H9ClFN |
| Molecular Weight | 173.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (1S)-1-(3-chloro-2-fluorophenyl)ethan-1-amine.
(1S)-1-(3-chloro-2-fluorophenyl)ethan-1-amine (CAS 1228561-56-5), molecular formula C8H9ClFN and molecular weight 173.62 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (1S)-1-(3-chloro-2-fluorophenyl)ethan-1-amine (C8H9ClFN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), (1S)-1-(3-chloro-2-fluorophenyl)ethan-1-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H9ClFN |
| Molecular Weight | 173.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related S Standards
- 1-(2-Chloro-6-fluorophenyl)ethan-1-amine (CAS 1000878-44-3)
- (S)-1-(2-Chloro-6-fluorophenyl)ethanamine (CAS 1000922-53-1)
- (R)-1-(3-chloro-4-fluorophenyl)ethan-1-amine (CAS 1012305-33-7)
- 1-(3-Chloro-4-fluorophenyl)ethan-1-amine (CAS 1021239-38-2)
- 1-(4-Chloro-2-fluorophenyl)ethan-1-amine (CAS 1028405-72-2)
- 3-Chloro-N-ethyl-2-fluoroaniline (CAS 1040041-91-5)
- 3-Chloro-n-ethyl-4-fluoroaniline (CAS 106847-36-3)
- [(4-chloro-2-fluorophenyl)methyl](methyl)amine (CAS 1094641-62-9)
Recommended Standards
- (S)-1-(5-chloro-2-fluorophenyl)ethan-1-amine (CAS 1228557-23-0)
- 1-(3-Chloro-5-fluorophenyl)ethan-1-amine (CAS 1263284-21-4)
- (R)-1-(5-Chloro-2-fluorophenyl)ethan-1-amine (CAS 1217464-96-4)
- 1-(5-Chloro-2-fluorophenyl)ethan-1-amine (CAS 1270391-53-1)
- Methyl 2-methyl-3-nitropyridine-4-carboxylate (CAS 1434142-18-3)
- (R)-4-bromo-2,3-dihydro-1H-inden-1-ol (CAS 83808-07-5)
- 3-Iodo-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine hydrochloride (CAS 1956310-27-2)
- 2-chloro-N-cyclohexyl-N-phenylacetamide (CAS 100721-33-3)
- (4-Hydroxyphenyl)(piperazin-1-yl)methanone hydrochloride (CAS 1170576-51-8)
- Diacetin (contains Mono-, Tri-, Glycerol) (CAS CATO-C3D-5677)
- 5,7-Dichloro-2,3-diphenylquinoxaline (CAS 5227-63-4)
- 1-(2-Hydroxy-5-(tert-pentyl)phenyl)butan-1-one (CAS 854867-25-7)
- 3-(2-Methoxyphenyl)-2,2-dimethylpropan-1-amine hydrochloride (CAS 1306603-68-8)
- Antiarrhythmic peptide (cattle atrium) (CAS 81771-37-1)
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