4-Bromo-3-chlorobenzamide CAS 1228826-41-2
| CAS No. | 1228826-41-2 |
| Molecular Formula | C7H5BrClNO |
| Molecular Weight | 234.48 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Bromo-3-chlorobenzamide.
4-Bromo-3-chlorobenzamide (CAS 1228826-41-2) is a high-purity analytical reference standard with the molecular formula C7H5BrClNO and a molecular weight of 234.48 g/mol.
The molecular framework of 4-Bromo-3-chlorobenzamide (C7H5BrClNO) is characterized by an amide group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Bromo-3-chlorobenzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5BrClNO |
| Molecular Weight | 234.48 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 3-Bromo-2-chlorobenzamide (CAS 1007578-84-8)
- 1-(4-Bromo-6-chloropyridin-2-yl)ethanone (CAS 1060815-65-7)
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- 2-Bromo-1-(3-chloropyridin-4-yl)ethan-1-one (CAS 1187785-52-9)
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Recommended Standards
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- 1-(5-Bromo-6-chloropyridin-2-yl)ethanone (CAS 1256805-46-5)
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