Darifenacin Impurity 2 HBr CAS 1229355-35-4
| CAS No. | 1229355-35-4 |
| Molecular Formula | C18H18N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Darifenacin Impurity 2 HBr (C18H18N2HBr) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Darifenacin Impurity 2 HBr (CAS 1229355-35-4) is a certified pharmaceutical impurity reference standard with the molecular formula C18H18N2HBr and a molecular weight of 343.27 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H18N2 HBr |
| Molecular Weight | 343.27 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Darifenacin Standards
- Darifenacin Pyrrolidine Impurity Racemate (CAS 103887-32-7)
- Darifenacin Impurity A (CAS 1048979-16-3)
- Darifenacin(acetic Acid) Des-(5-Ethyl-2,3-dihydrobenzofuran) (Darifenacin Impurity) (CAS 1050646-75-7)
- Darifenacin R-Isomer Impurity (CAS 1092800-15-1)
- Darifenacin D4 (CAS 1095598-84-7)
- Darifenacin-D4 (CAS 1189701-43-6)
- (R)-Darifenacin-d (CAS 1261394-25-5)
- Darifenacin USP Related Compound G (CAS 127264-14-6)
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