N-(4-Chlorophenyl)-2,6-difluorobenzamide CAS 122987-01-3
| CAS No. | 122987-01-3 |
| Molecular Formula | C13H8ClF2NO |
| Molecular Weight | 267.66 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of N-(4-Chlorophenyl)-2,6-difluorobenzamide (C13H8ClF2NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
N-(4-Chlorophenyl)-2,6-difluorobenzamide (CAS 122987-01-3) is a high-purity analytical reference standard with the molecular formula C13H8ClF2NO and a molecular weight of 267.66 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H8ClF2NO |
| Molecular Weight | 267.66 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related N Standards
- N-(2-Chlorophenyl)-2,6-difluorobenzamide (CAS 883043-20-7)
- N-(3-Chlorophenyl)-2,6-difluorobenzamide (CAS 937648-67-4)
- N-(4-chlorophenyl)-2,4-difluorobenzamide (CAS 865660-62-4)
- Ethyl (5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)carbamate (CAS 116221-81-9)
- 1-(2-(3-Chlorophenyl)-2-hydroxyethyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1338691-83-0)
- Methyl 3-[(4-Chlorophenyl)(hydroxy)methyl]isoxazole-4-carboxylate (CAS 2006277-98-9)
- n-(4-chlorophenyl)-2-(2,5-dioxo-1-imidaZolidinyl)acetamide (CAS 638991-67-0)
- 3-{[2-(4-chlorophenyl)ethyl]amino}-1,1,1-trifluoropropan-2-ol (CAS 1410612-84-8)
Recommended Standards
- 2-(4-Chloro-2-fluorobenzenesulfonamido)acetic acid (CAS 1097796-13-8)
- 2-(5-Chloro-2-(difluoromethyl)benzoyl)pyridine (CAS 1261451-49-3)
- 3-Chloro-N-(2,6-difluorophenyl)benzamide (CAS 1065134-57-7)
- 2-(3-Chloro-5-(difluoromethyl)benzoyl)pyridine (CAS 1261594-63-1)
- 3-{[4-(trifluoromethyl)phenyl]sulfanyl}propanoic acid (CAS 19372-88-4)
- 5-Isopropyl-2,3-dimethylpyridin-4-amine (CAS 2397623-64-0)
- 3-(Phenylsulfanyl)propan-1-ol (CAS 24536-40-1)
- rel-tert-Butyl (3R,4R)-4-methylpyrrolidin-3-ylcarbamate oxalate (CAS 2459946-05-3)
- 2-Amino-4-cyclohexyl-thiophene-3-carboxylic acid ethyl ester (CAS 149588-08-9)
- Fmoc-Nva-OH (CAS 135112-28-6)
- 4-(1-methyl-1H-1,2,3,4-tetrazol-5-yl)aniline (CAS 382637-68-5)
- 2-(4-Ethylphenoxy)ethanamine (CAS 67333-08-8)
- 2-(4-Methoxycyclohexa-1,4-dien-1-yl)propan-2-ol (CAS 61597-37-3)
- Des-Trp25-Tirzepatide (CAS CATO-CPTD788948)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com