3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-ethoxy-3-cyclobutene-1,2-dione CAS 1233032-09-1
| CAS No. | 1233032-09-1 |
| Molecular Formula | C14H9F6NO3 |
| Molecular Weight | 353.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-ethoxy-3-cyclobutene-1,2-dione.
3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-ethoxy-3-cyclobutene-1,2-dione (CAS 1233032-09-1) is a high-purity analytical reference standard with the molecular formula C14H9F6NO3 and a molecular weight of 353.22 g/mol.
3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-ethoxy-3-cyclobutene-1,2-dione (C14H9F6NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-ethoxy-3-cyclobutene-1,2-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H9F6NO3 |
| Molecular Weight | 353.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Bis Standards
- 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-methoxy-3-cyclobutene-1,2-dione (CAS 1073917-05-1)
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- Ethyl 2-(3-{[3-(trifluoromethyl)anilino]carbonyl}-2-pyridinyl)acetate (CAS 338392-12-4)
- 5-(Trifluoromethyl)-2-(1-{[5-(trifluoromethyl)pyridin-2-yl]sulfanyl}ethyl)pyridine (CAS 1092345-95-3)
Recommended Standards
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- N-(2,4-Dichlorophenyl)quinoline-8-sulfonamide (CAS 158729-27-2)
- Isopropyl 4-(2-bromophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 300690-02-2)
- N-(3,4-dichlorophenyl)quinoline-8-sulfonamide (CAS 158729-28-3)
- 7-Methyl-1-phenyl-1H-pyrido[2,3-d][1,3]oxazine-2,4-dione (CAS 1253791-80-8)
- 1-(Dodecyloxy)-4-((4-ethynylphenyl)ethynyl)benzene (CAS 364621-99-8)
- 6-Methoxy-1-((4-methoxyphenyl)sulfonyl)-1H-indole-3-carbaldehyde (CAS 651331-51-0)
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- Methyl 5-benzamidobenzo[b]thiophene-2-carboxylate (CAS 477847-53-3)
- 2-(2-Ethoxy-2-oxoethyl)isoquinolin-2-ium chloride (CAS 54817-42-4)
- Ruthenium, [1,1'-bis[bis(1-methylethyl)phosphino-κP]ferrocene]dichloro(1,2-ethanediamine-κN,κN')-, (OC-6-13) (CAS 899444-57-6)
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