4-Chloro-2-fluoro-6-(trifluoromethyl)aniline CAS 1235441-41-4
| CAS No. | 1235441-41-4 |
| Molecular Formula | C7H4ClF4N |
| Molecular Weight | 213.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-Chloro-2-fluoro-6-(trifluoromethyl)aniline.
4-Chloro-2-fluoro-6-(trifluoromethyl)aniline (CAS 1235441-41-4), molecular formula C7H4ClF4N and molecular weight 213.56 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Chloro-2-fluoro-6-(trifluoromethyl)aniline (C7H4ClF4N) is characterized by a nitrile group, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H4ClF4N |
| Molecular Weight | 213.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 2-Chloro-5-fluoro-3-(trifluoromethyl)aniline (CAS 105172-78-9)
- 3-Chloro-2-fluoro-6-(trifluoromethyl)aniline (CAS 1092461-38-5)
- 5-Chloro-2-fluoro-4-(trifluoromethyl)aniline (CAS 114973-23-8)
- 2-Chloro-3-fluoro-4-(trifluoromethyl)aniline (CAS 123418-97-3)
- 2-Chloro-4-fluoro-6-(trifluoromethyl)aniline (CAS 1235439-54-9)
- 2-Chloro-6-fluoro-4-(trifluoromethyl)aniline (CAS 123973-31-9)
- 2-Chloro-4-fluoro-5-(trifluoromethyl)aniline (CAS 125508-25-0)
- 3-Chloro-2-fluoro-5-(trifluoromethyl)aniline (CAS 126538-85-0)
Recommended Standards
- 4-Chloromethyl-2-fluoro-5-(trifluoromethyl)pyridine (CAS 1227594-70-8)
- 2-Chloromethyl-3-fluoro-6-(trifluoromethyl)pyridine (CAS 1227590-95-5)
- 2-(Chloromethyl)-6-fluoro-4-(trifluoromethyl)pyridine (CAS 1393557-62-4)
- 4-Chloromethyl-2-fluoro-3-(trifluoromethyl)pyridine (CAS 1227581-18-1)
- 5-[4-(Cyclopentyloxy)phenyl]-1,3,4-oxadiazol-2-amine (CAS 1219827-71-0)
- (R)-N-(2-nitrophenyl)pyrrolidin-3-amine hydrochloride (CAS 1417789-20-8)
- 1-(5-Chlorospiro[indoline-3,4'-piperidin]-1-yl)ethanone (CAS 637362-19-7)
- 3-Bromo-2-fluoro-5-(trifluoromethyl)aniline (CAS 1262198-06-0)
- 1040078-30-5 7863AC C14H23NO N-(2-Ethoxyphenyl)-N-hexylamine (CAS 1040078-30-5)
- (2S,3R,4R,5R)-2-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile (CAS 2324118-49-0)
- 2-(Methylthio)-4-(p-tolylamino)pyrimidine-5-carboxylicacid (CAS 1033194-60-3)
- 3,3-Dimethyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid (CAS 127267-57-6)
- 2-[3-(Trifluoromethyl)phenoxy]-5-[3-(trifluoromethyl)phenyl]pyridine-3-carbonitrile (CAS 338964-65-1)
- Des-Ala18-Tirzepatide (CAS CATO-CPTD788955)
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