(3',4',5'-Trifluoro-[1,1'-biphenyl]-4-yl)boronic acid CAS 1236159-62-8
| CAS No. | 1236159-62-8 |
| Molecular Formula | C12H8BF3O2 |
| Molecular Weight | 252.00 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), (3',4',5'-Trifluoro-[1,1'-biphenyl]-4-yl)boronic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
(3',4',5'-Trifluoro-[1,1'-biphenyl]-4-yl)boronic acid (CAS 1236159-62-8), molecular formula C12H8BF3O2 and molecular weight 252.00 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, (3',4',5'-Trifluoro-[1,1'-biphenyl]-4-yl)boronic acid (C12H8BF3O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 7.5, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 252.00 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H8BF3O2 |
| Molecular Weight | 252.00 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Trifluoro Standards
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- 2,2,2-Trifluoro-N-(4-fluoro-3-nitrophenyl)acetamide (CAS 64182-71-4)
- 2-(2,2,2-Trifluoro-1-(3-fluorophenyl)ethoxy)acetic acid (CAS 1437432-67-1)
- 2-(2,2,2-Trifluoro-1-(2-fluorophenyl)ethoxy)acetic acid (CAS 1437456-10-4)
- 4,4,4-Trifluoro-3-(4-fluorophenyl)-3-hydroxybutanoic acid (CAS 1514656-55-3)
- 2,2,2-Trifluoro-1-(2-fluoro-4,5-dimethoxyphenyl)ethanone (CAS 1516199-30-6)
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Recommended Standards
- 3-Acetyl-4-((difluoroboranyl)oxy)-2H-chromen-2-one (CAS 873326-02-4)
- 5-Bromo-4,4,5,5-tetrafluoropentanamide (CAS 1309602-30-9)
- NH2-MIL-53(Fe) (CAS 1291088-77-1)
- 4-Iodo-1H-pyrazole-3-carbohydrazide (CAS 1005592-09-5)
- 1-(Methoxymethyl)cyclohexane-1-carbaldehyde (CAS 269072-13-1)
- 2,5-Dimethyl-4-nitrobenzonitrile (CAS 73713-69-6)
- 4-bromo-3-methyl-1H-indazole (CAS 1159511-73-5)
- 4-Hydroxy-1-benzothiophene-2-sulfonamide (CAS 96803-90-6)
- N-(ε-Aminocaproyl)-β-L-fucopyranosylamine (CAS 35978-97-3)
- Ethyl 5-(furan-2-yl)-7-(trifluoromethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 667920-77-6)
- 3-(1,3-Dimethyl-1H-pyrazol-4-yl)-2-thioxoimidazolidin-4-one (CAS 1004020-66-9)
- 1H-Imidazo[4,5-c]pyridine, 4,5,6,7-tetrahydro-1-methyl-7-[[(2-methyl-4-thiazolyl)methoxy]methyl]- (CAS 1422133-33-2)
- 4-Chloro-5-methyl-5,7-dihydrofuro[3,4-d]pyrimidine (CAS 1000984-97-3)
- Liraglutide Impurity 15 TFA Salt (CAS CATO-C4X-199215)
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