Bumetanide Impurity N3 CAS 1236290-34-8
| CAS No. | 1236290-34-8 |
| Molecular Formula | C21H28N2O5S |
| Molecular Weight | 420.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Bumetanide Impurity N3.
Bumetanide Impurity N3 (CAS 1236290-34-8) is a certified pharmaceutical impurity reference standard with the molecular formula C21H28N2O5S and a molecular weight of 420.52 g/mol.
Bumetanide Impurity N3 (C21H28N2O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H28N2O5S |
| Molecular Weight | 420.52 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Bumetanide Standards
- Bumetanide EP Impurity C (CAS 32643-00-8)
- Bumetanide EP Impurity D (CAS 153012-65-8)
- Bumetanide Impurity N1 (CAS 28469-01-4)
- Bumetanide Impurity 131 (CAS CATO-C4X-1986131)
- Bumetanide Impurity 60 (CAS CATO-C4X-198660)
- Bumetanide Impurity 132 (CAS CATO-C4X-1986132)
- Bumetanide-d5 Butyl Ester (CAS 1216685-32-3)
- Bumetanide Impurity 134 (CAS CATO-C4X-1986134)
Recommended Standards
- Levocabastine EP Impurity I (CAS CATO-C4X-22899)
- Levocabastine EP Impurity E (CAS CATO-C4X-22895)
- 3-Methoxy-N-[(1-methyl-1H-pyrazol-4-yl)methyl]-N-[2-(piperidin-1-ylsulfonyl)ethyl]benzamide (CAS 1010865-42-5)
- Levocabastine EP Impurity C (CAS CATO-C4X-22893)
- Tucatinib Impurity 10 (CAS CATO-C4X-260510)
- Carbamazepine EP Impurity F (CAS 33948-22-0)
- Esomeprazole impurity 143 (CAS 153476-69-8)
- N1-Benzyl-N2-(sec-butyl)oxalamide (CAS 351997-82-5)
- 8-Chloro-2,3,4,4a,5,9b-hexahydro-1H-pyrido[4,3-b]indole dihydrochloride (CAS 1187931-90-3)
- 4-Bromo-2-(trifluoromethyl)oxazole (CAS 1240603-57-9)
- 4-Chloro-5-((4-methoxybenzyl)oxy)-2-propylpyridazin-3(2H)-one (CAS 88094-10-4)
- (2R)-3-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-2-(4-fluorophenyl)propanoic acid 1280787-12-3 GS-0826 (CAS 1280787-12-3)
- 1-(2-Chloro-4-methoxyphenyl)ethanone (CAS 41068-36-4)
- Semaglutide Impurity 145 (CAS CATO-C4X-2226145)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com