2-Fluoro-3-(trifluoromethyl)aniline CAS 123973-25-1
| CAS No. | 123973-25-1 |
| Molecular Formula | C7H5F4N |
| Molecular Weight | 179.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 2-Fluoro-3-(trifluoromethyl)aniline (CAS 123973-25-1), a certified reference material (molecular formula C7H5F4N, MW 179.11 g/mol) for analytical method development and quality control.
The molecular framework of 2-Fluoro-3-(trifluoromethyl)aniline (C7H5F4N) is characterized by a nitrile group, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 2-Fluoro-3-(trifluoromethyl)aniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5F4N |
| Molecular Weight | 179.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoro Standards
- 3-Fluoro-2-(trifluoromethyl)aniline (CAS 123973-22-8)
- 2-Fluoro-4-methyl-5-trifluoromethyl-pyridine (CAS 1246466-55-6)
- 3-Fluoro-2-methyl-5-(trifluoromethyl)pyridine (CAS 1260790-61-1)
- 2-Fluoro-5-(trifluoromethyl)aniline (CAS 535-52-4)
- 3-Fluoro-4-(trifluoromethyl)aniline (CAS 69411-68-3)
- 5-Fluoro-2-(trifluoromethyl)aniline (CAS 827-20-3)
- 5-Fluoro-2-methyl-3-(trifluoromethyl)pyridine (CAS 2089325-73-3)
- 4-Fluoro-2-(trifluoromethyl)aniline (CAS 393-39-5)
Recommended Standards
- <I>N</I>-acetyl-<SC>L</SC>-aspartic acid-1,2,3,4-<SUP>13</SUP>C<SUB>4</SUB > (CAS 1217460-88-2)
- 1-Bromoheptane (CAS 629-04-9)
- 2,4-Difluoro-3-(difluoromethyl)aniline (CAS 1638328-80-9)
- 6-Amino-5-(trifluoromethyl)pyrimidin-2(1H)-one (CAS 24101-10-8)
- (S)-2-Amino-N-((S)-1-benzylpyrrolidin-3-yl)-3-methylbutanamide (CAS 1401665-24-4)
- 5-(Methylthio)furan-2-carboxylic acid (CAS 21984-78-1)
- 2-Methyl-1-(oxiran-2-ylmethyl)-1H-indole-3-carbaldehyde (CAS 1142202-07-0)
- Nickel, [5,10,15,20-tetra-4-pyridinyl-21H,23H-porphinato(2-)-κN21,κN22,κN23,κN24]-, (SP-4-1)- (CAS 14514-68-2)
- 4-Chloro-1-(pyrimidin-2-yl)-1h-pyrazolo[3,4-d]pyrimidine (CAS 630107-87-8)
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