tert-Butyl 3-(difluoromethyl)piperazine-1-carboxylate CAS 1240621-52-6
| CAS No. | 1240621-52-6 |
| Molecular Formula | C10H18F2N2O2 |
| Molecular Weight | 236.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
tert-Butyl 3-(difluoromethyl)piperazine-1-carboxylate (CAS 1240621-52-6), molecular formula C10H18F2N2O2 and molecular weight 236.26 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, tert-Butyl 3-(difluoromethyl)piperazine-1-carboxylate is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 236.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), tert-Butyl 3-(difluoromethyl)piperazine-1-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H18F2N2O2 |
| Molecular Weight | 236.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
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- Ethyl 2-(4-methoxy-2,5-dimethylphenyl)-2-oxoacetate (CAS 1226237-40-6)
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- 2-Cyano-3-(4-methoxyphenyl)propanamide (CAS 91350-79-7)
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- Dichloro [(R)-(+)-2,2-bis(diphenylphosphino)-1,1-binaphathyl] ruthenium(II) (CAS 132071-87-5)
- 4-(Boc-amino)-1-Cbz-piperidine-4-carboxylic Acid (CAS 252720-32-4)
- 1-Amino-4-(dimethylamino)cyclohexanecarboxylic acid (CAS 1785260-27-6)
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