4-(tert-Butyl)-3-cyclopropoxy-5-(trifluoromethyl)pyridine CAS 1243463-85-5
| CAS No. | 1243463-85-5 |
| Molecular Formula | C13H16F3NO |
| Molecular Weight | 259.27 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(tert-Butyl)-3-cyclopropoxy-5-(trifluoromethyl)pyridine (C13H16F3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
4-(tert-Butyl)-3-cyclopropoxy-5-(trifluoromethyl)pyridine (CAS 1243463-85-5), molecular formula C13H16F3NO and molecular weight 259.27 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-(tert-Butyl)-3-cyclopropoxy-5-(trifluoromethyl)pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H16F3NO |
| Molecular Weight | 259.27 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 2-(tert-Butyl)-3-cyclopropoxy-6-(trifluoromethyl)pyridine (CAS 1243461-70-2)
- 6-Methyl-3-(trifluoromethyl)pivalanilide (CAS 1246819-76-0)
- 2-(tert-Butyl)-4-cyclopropoxy-6-(trifluoromethyl)pyridine (CAS 1243459-73-5)
- Azatepa (CAS 125-45-1)
- N,N-Dimethylaniline-d11 (CAS 85785-00-8)
- 2-Amino-5,6-dichloro-3(4H)-quinazoline Acetic Acid Hydrobromide (Anagrelide Impurity B) (CAS 1194434-39-3)
- Manganese(II) (E)-(1-(dimethylamino)hex-1-en-2-yl)(isopropyl)amide (CAS 1188406-04-3)
- Z-ILE-MET-OH (CAS 84030-22-8)
- 1-{3-Bromoimidazo[1,2-b]pyridazin-6-yl}piperidine (CAS 952182-14-8)
- 2-(2-Phenylethoxy)aniline (CAS 97476-32-9)
- 3-Methylenepyrrolidine (CAS 164650-60-6)
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- 2-(4,4-Dimethyl-1,2,3,4-tetrahydronaphthalen-1-yl)ethan-1-amine (CAS 1226179-43-6)
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