2-(tert-Butyl)-4-cyclopropoxy-6-iodopyridine CAS 1243464-86-9
| CAS No. | 1243464-86-9 |
| Molecular Formula | C12H16INO |
| Molecular Weight | 317.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(tert-Butyl)-4-cyclopropoxy-6-iodopyridine (CAS 1243464-86-9) is a high-purity analytical reference standard with the molecular formula C12H16INO and a molecular weight of 317.17 g/mol.
The molecular framework of 2-(tert-Butyl)-4-cyclopropoxy-6-iodopyridine (C12H16INO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 2-(tert-Butyl)-4-cyclopropoxy-6-iodopyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H16INO |
| Molecular Weight | 317.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 3-(tert-Butyl)-5-cyclopropoxy-2-iodopyridine (CAS 1243461-02-0)
- N-[(4-Iodophenyl)methyl]oxan-4-amine (CAS 1245710-94-4)
- 2-(tert-Butyl)-3-cyclopropoxy-6-iodopyridine (CAS 1243452-89-2)
- 2-((4-Iodophenoxy)methyl)piperidine (CAS 1247605-01-1)
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