2-(Isopropylthio)-1H-benzimidazole CAS 124530-70-7
| CAS No. | 124530-70-7 |
| Molecular Formula | C10H12N2S |
| Molecular Weight | 192.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(Isopropylthio)-1H-benzimidazole (CAS 124530-70-7), molecular formula C10H12N2S and molecular weight 192.28 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(Isopropylthio)-1H-benzimidazole (C10H12N2S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12N2S |
| Molecular Weight | 192.28 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Isopropylthio Standards
- 5-(Isopropylthio)-1,3,4-thiadiazole-2-thiol (CAS 62868-67-1)
- 3-(Isopropylthio)phenylboronic acid (CAS 2096332-50-0)
- 3-(Isopropylthio)benzoic acid (CAS 114838-12-9)
- 4-(Isopropylthio)benzoic acid (CAS 13205-50-0)
- 1-(Isopropylthio)-3-methylcyclobutane-1-carboxylic acid (CAS 1491215-13-4)
- 2-(Isopropylthio)benzoic acid (CAS 41394-95-0)
- 5-(Isopropylthio)-3-methylimidazolidine-2,4-dione (CAS 64732-01-0)
- 1-(Isopropylthio)-3-oxocyclobutane-1-carboxylic acid (CAS 1494424-54-2)
Recommended Standards
- 1-Methanesulfonyl-3-methylpiperidin-4-amine (CAS 1228453-26-6)
- n-Methyl-1-(piperidin-3-yl)methanesulfonamide (CAS 1247670-75-2)
- rel-(3R,4S)-3-Methyl-1-(methylsulfonyl)piperidin-4-amine (CAS 1228449-78-2)
- 1-(pyridin-2-yl)ethane-1-sulfonamide (CAS 1249535-80-5)
- (3R, 4S, 5S)-oseltamivir diallyl compound (CAS CATO-C4X-1720215)
- Tert-butyl 4-(4-nitrobenzyl)piperazine-1-carboxylate (CAS 130636-61-2)
- 4,6-Dibromoisophthalonitrile (CAS 244261-21-0)
- 5,6,7-Trifluoro-2,3-dihydro-1h-inden-1-one (CAS 1257844-57-7)
- 3,6-Dimethyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 54504-62-0)
- 2,3,5-Trichlorothiophene (CAS 17249-77-3)
- 3,5-Dinitrobenzonitrile (CAS 4110-35-4)
- (9H-fluoren-9-yl)methyl ((R)-1-(((S)-6-((tert-butoxycarbonyl)amino)-1-oxo-1-(4-(pyridin-4-yl)piperazin-1-yl)hexan-2-yl)amino)-3-(3,5-dibromo-4-hydroxyphenyl)-1-oxopropan-2-yl)carbamate (CAS 204693-24-3)
- Methyl 3-(4-oxo-7-(trifluoromethyl)quinolin-1(4H)-yl)propanoate (CAS 1279207-56-5)
- Semaglutide impound 212 (CAS CATO-C4X-2226212)
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