Methyl 8-chloroisoquinoline-5-carboxylate CAS 1246441-85-9
| CAS No. | 1246441-85-9 |
| Molecular Formula | C11H8ClNO2 |
| Molecular Weight | 221.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Methyl 8-chloroisoquinoline-5-carboxylate (C11H8ClNO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Methyl 8-chloroisoquinoline-5-carboxylate (CAS 1246441-85-9) is a high-purity analytical reference standard with the molecular formula C11H8ClNO2 and a molecular weight of 221.64 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H8ClNO2 |
| Molecular Weight | 221.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Methyl Standards
- Methyl 1-chloroisoquinoline-7-carboxylate (CAS 1206975-02-1)
- Methyl 1-chloroisoquinoline-5-carboxylate (CAS 1206979-27-2)
- Methyl 3-chloroisoquinoline-4-carboxylate (CAS 1260642-58-7)
- Methyl 1-chloroisoquinoline-6-carboxylate (CAS 1357946-43-0)
- Methyl 7-chloroisoquinoline-4-carboxylate (CAS 1367827-00-6)
- Methyl 3-chloroisoquinoline-6-carboxylate (CAS 1416713-88-6)
- Methyl 3-chloroisoquinoline-5-carboxylate (CAS 1432514-90-3)
- Methyl 3-chloroisoquinoline-8-carboxylate (CAS 1432514-94-7)
Recommended Standards
- 1-Chloro-6-methylisoquinoline-5-carboxylic acid (CAS 1245643-02-0)
- 3-Chloro-4-(pyridazin-3-yloxy)aniline (CAS 1249676-11-6)
- 2-Chloro-4-methylquinoline-7-carboxylic acid (CAS 124307-93-3)
- 2-(2-Chloropyridin-4-yl)-6-methylpyrimidin-4(3H)-one (CAS 1258640-22-0)
- Diclofenac Isopropyl Ester (CAS 66370-79-4)
- 2,2,2-Trifluoro-1-(1-phenylcyclopentyl)ethan-1-one (CAS 2229145-09-7)
- 2-mercapto-3-octyl-6,7,8,9-tetrahydro-3H-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4(5H)-one (CAS 380437-06-9)
- 2',4'-Difluoro-[1,1'-biphenyl]-4-carboxylic acid (CAS 331760-41-9)
- Ceftriaxone Impurity 44 (CAS CATO-C4X-116344)
- 5-((4-Fluorophenyl)thio)-1,3-diphenyl-1H-pyrazole-4-carbaldehyde (CAS 955964-28-0)
- 2-(Cyclopropylmethoxy)nicotinonitrile (CAS 1019493-32-3)
- H-Pro-Asp-OH (CAS 85227-98-1)
- Cyclopropyl(1,4-dioxan-2-yl)methanamine (CAS 1495075-33-6)
- Semaglutide Impurity 180 (CAS CATO-C4X-2226180)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com