Methyl 4-(4-chloro-3-fluorophenyl)-4-oxobutanoate CAS 1247500-98-6
| CAS No. | 1247500-98-6 |
| Molecular Formula | C11H10ClFO3 |
| Molecular Weight | 244.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 4-(4-chloro-3-fluorophenyl)-4-oxobutanoate.
Methyl 4-(4-chloro-3-fluorophenyl)-4-oxobutanoate (CAS 1247500-98-6), molecular formula C11H10ClFO3 and molecular weight 244.65 g/mol, is a CATO reference standard with documented purity and traceability.
Methyl 4-(4-chloro-3-fluorophenyl)-4-oxobutanoate (C11H10ClFO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Methyl 4-(4-chloro-3-fluorophenyl)-4-oxobutanoate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H10ClFO3 |
| Molecular Weight | 244.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
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- 2-Bromo-5-chloro-4-fluorobenzoic acid (CAS 1519109-81-9)
- 3-(4-Bromophenyl)piperidine (CAS 769944-72-1)
- (2S,3R)-3,4-Dihydro-3-isopropyl-2-phenyl-2H-pyrimido[2,1-b]benzothiazole (CAS 1203507-02-1)
- Boc-N-Me-Ser-OH (CAS 101772-29-6)
- 2-Bromo-6-(trifluoromethyl)pyridin-4-amine (CAS 1806857-87-3)
- 7-fluoro-2,3-dihydrobenzofuran-4-ol (CAS 1232774-17-2)
- 1-(4-Bromophenyl)-2-(4-methylpiperazin-1-yl)ethanone (CAS 845289-18-1)
- Insulin Degludec Impurity 20 (CAS CATO-C4X-215720)
Why CATO?
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