4-Methyl-3-trifluoromethylbenzenesulfonamide CAS 1247548-96-4
| CAS No. | 1247548-96-4 |
| Molecular Formula | C8H8F3NO2S |
| Molecular Weight | 239.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Methyl-3-trifluoromethylbenzenesulfonamide (CAS 1247548-96-4), molecular formula C8H8F3NO2S and molecular weight 239.21 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, 4-Methyl-3-trifluoromethylbenzenesulfonamide is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 239.21 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8F3NO2S |
| Molecular Weight | 239.21 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Recommended Standards
- 2-methyl-3-(trifluoromethyl)benzene-1-sulfonamide (CAS 1208074-79-6)
- Diethyl (2-(methoxy(methyl)amino)-2-oxoethyl)phosphonate (CAS 124931-12-0)
- n-Ethyl-2,4,6-trifluorobenzenesulfonamide (CAS 1183961-57-0)
- 2-Methyl-5-(trifluoromethyl)benzenesulfonamide (CAS 1261650-49-0)
- N-(1H-Indazol-4-yl)-2,2-dimethylpropanamide (CAS 685108-37-6)
- (3,4-Difluorophenyl)(4-ethylphenyl)methanone (CAS 845781-02-4)
- 2-{4-[1-(methylamino)ethyl]phenyl}-1,2-thiazolidine-1,1-dione (CAS 1155097-10-1)
- 7-[2-(2,6-dioxo-3-piperidyl)-1-oxo-isoindolin-4-yl]heptanal (CAS 2762039-44-9)
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- Semaglutide (CAS 910463-68-2（free base）)
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