2-(3,5-Difluorophenyl)-2-methylpropanenitrile CAS 1249436-65-4
| CAS No. | 1249436-65-4 |
| Molecular Formula | C10H9F2N |
| Molecular Weight | 181.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(3,5-Difluorophenyl)-2-methylpropanenitrile (CAS 1249436-65-4), molecular formula C10H9F2N and molecular weight 181.18 g/mol, is a CATO reference standard with documented purity and traceability.
2-(3,5-Difluorophenyl)-2-methylpropanenitrile (C10H9F2N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 2-(3,5-Difluorophenyl)-2-methylpropanenitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9F2N |
| Molecular Weight | 181.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluorophenyl Standards
- 2-(3,4-Difluorophenyl)-2-methylpropanenitrile (CAS 1035262-16-8)
- 4-(2,6-difluorophenyl)butanenitrile (CAS 1057672-27-1)
- 5-(2,5-Difluorophenyl)-3,4-dihydro-2H-pyrrole (CAS 1443623-92-4)
- 2-(2,3-Difluorophenyl)-2-methylpropanenitrile (CAS 913719-86-5)
- 2-(2,6-Difluorophenyl)-2-methylpropanenitrile (CAS 913719-87-6)
- 5-(3,5-Difluorophenyl)-1,3-oxazole (CAS 1235340-39-2)
- 5-(2,6-Difluorophenyl)isoxazole (CAS 138716-41-3)
- 5-(2,4-Difluorophenyl)isoxazole (CAS 138716-46-8)
Recommended Standards
- (R)-2,2,2-trifluoro-1-(thiophen-3-yl)ethan-1-amine (CAS 1213668-43-9)
- 2,2-Difluoro-3-morpholinopropan-1-ol (CAS 1314398-32-7)
- (S)-2,2,2-trifluoro-1-(thiophen-2-yl)ethan-1-amine (CAS 1213063-48-9)
- 2-(Difluoromethyl)-3-methyl-1H-indole (CAS 1379263-70-3)
- (S)-7-Chloro-2,3-dihydro-1H-inden-1-ol (CAS 1270301-79-5)
- (2E)-1-{[1,1'-Biphenyl]-4-yl}-3-(2-methoxyphenyl)prop-2-en-1-one (CAS 1539275-18-7)
- 3,6-Dichloro-1-methyl-1h-indole-2-carboxylic acid (CAS 1355224-53-1)
- (S)-3-(1-Methyl-1H-indol-3-yl)butanenitrile (CAS 429689-24-7)
- n-(Piperidin-3-ylmethyl)thiophene-3-carboxamide hydrochloride (CAS 1185313-04-5)
- 3-(Sec-butyl)-2-mercapto-3,5,6,7,8,9-hexahydro-4h-cyclohepta[4,5]thieno[2,3-d]pyrimidin-4-one (CAS 750601-57-1)
- 4'-(Benzyloxy)-[1,1'-biphenyl]-2-amine (CAS 400746-75-0)
- Ethyl 2-ethoxy-3,4,5,6-tetrahydropyridine-3-carboxylate (CAS 3731-15-5)
- 2-(3-(2-Fluorophenyl)-2-oxoimidazolidin-1-yl)-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide (CAS 1257553-24-4)
- Allo-D-Ile12-Tirzepatide (CAS CATO-CPTD788963)
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