3-Methyl-N-(2,2,2-trifluoroethyl)pyridin-2-amine CAS 1249476-75-2
| CAS No. | 1249476-75-2 |
| Molecular Formula | C8H9F3N2 |
| Molecular Weight | 190.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 190.17 g/mol gives 3-Methyl-N-(2,2,2-trifluoroethyl)pyridin-2-amine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-Methyl-N-(2,2,2-trifluoroethyl)pyridin-2-amine (CAS 1249476-75-2) is a high-purity analytical reference standard with the molecular formula C8H9F3N2 and a molecular weight of 190.17 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, 3-Methyl-N-(2,2,2-trifluoroethyl)pyridin-2-amine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 190.17 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9F3N2 |
| Molecular Weight | 190.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- N,N-dimethyl-6-(trifluoromethyl)pyridin-2-amine (CAS 1233509-67-5)
- (R)-1-(2-(Trifluoromethyl)pyridin-4-yl)ethanamine (CAS 1256810-98-6)
- 3-(Aminomethyl)-5-(trifluoromethyl)aniline (CAS 1233324-80-5)
- 1-Phenyl-2-(2,2,2-trifluoroethyl)hydrazine (CAS 1258979-48-4)
- Methyl4-acetamido-3-iodobenzoate (CAS 190071-23-9)
- 1-Cyclopentyl-2-(phenylthio)ethan-1-one (CAS 127869-09-4)
- 4-Iodo-1-methoxy-2-(trifluoromethyl)benzene (CAS 1261761-96-9)
- Tert-butyl (1S,5S)-3,9-diazabicyclo[3.3.2]Decane-9-carboxylate hydrochloride (CAS 2126144-61-2)
- 4,6-Dimethyl-2-morpholinonicotinonitrile (CAS 142591-26-2)
- Dichloro{(1R,2R)-N,N-bis[2-(diphenylphosphino)benzyl]cyclohexane-1,2-diamine}ruthenium(II) (CAS 429678-11-5)
- 2-(Aminomethyl)-3-(difluoromethyl)-5-methoxypyridine-4-carboxylic acid (CAS 1361820-05-4)
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- 4-Cyclopropoxy-N-methyl-2-nitrobenzamide (CAS 1243283-16-0)
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