1-(3-Chloro-4-fluorophenyl)ethane-1-sulfonyl chloride CAS 1250596-49-6
| CAS No. | 1250596-49-6 |
| Molecular Formula | C8H7Cl2FO2S |
| Molecular Weight | 257.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
1-(3-Chloro-4-fluorophenyl)ethane-1-sulfonyl chloride (CAS 1250596-49-6) is a high-purity analytical reference standard with the molecular formula C8H7Cl2FO2S and a molecular weight of 257.11 g/mol.
The molecular framework of 1-(3-Chloro-4-fluorophenyl)ethane-1-sulfonyl chloride (C8H7Cl2FO2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 1-(3-Chloro-4-fluorophenyl)ethane-1-sulfonyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7Cl2FO2S |
| Molecular Weight | 257.11 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Sulfur Atoms | 1 |
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