8-Bromo-4-chloroquinazoline CAS 125096-72-2
| CAS No. | 125096-72-2 |
| Molecular Formula | C8H4BrClN2 |
| Molecular Weight | 243.49 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 8-Bromo-4-chloroquinazoline is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
8-Bromo-4-chloroquinazoline (CAS 125096-72-2), molecular formula C8H4BrClN2 and molecular weight 243.49 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 8-Bromo-4-chloroquinazoline (C8H4BrClN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 243.49 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H4BrClN2 |
| Molecular Weight | 243.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 2 |
Related Bromo Standards
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- 3-Bromo-7-chlorocinnoline (CAS 1083181-45-6)
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- 8-Bromo-2-chloroquinoxaline (CAS 1092500-67-8)
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- 6-Bromo-7-chloroquinoxaline (CAS 1210047-58-7)
- 6-Bromo-5-chloroquinoxaline (CAS 1210047-63-4)
- 3-Bromo-5-chloro-1,6-naphthyridine (CAS 1211588-58-7)
Recommended Standards
- 6-Bromo-2-chloro-1,7-naphthyridine (CAS 1246554-46-0)
- 8-Bromo-4-chloro-1,6-naphthyridine (CAS 1259061-05-6)
- 2-Bromo-6-chloro-1,7-naphthyridine (CAS 1246549-09-6)
- 2-Bromo-8-chloro-1,7-naphthyridine (CAS 1260666-72-5)
- (5R,8r)-2-azaspiro[4.5]Decan-8-ol (CAS 1932498-08-2)
- 2-Ethyl-4,5-dimethylthieno[2,3-d]pyrimidine-6-carboxylic acid (CAS 929975-02-0)
- 4-(4-Methyl-piperazine-1-carbonyl)benzaldehyde (CAS 58287-81-3)
- 4-Fluoro-2-nitro-N-propylaniline (CAS 35538-23-9)
- 3-(N-butylsulfamoyl)benzoic acid (CAS 7385-16-2)
- 2-(3-Methoxyazetidin-1-yl)acetic acid (CAS 1781971-45-6)
- 2-Amino-3-(2-hydroxy-5-methylphenyl)propanoic acid (CAS 24146-05-2)
- O-(pyridin-2-ylmethyl)hydroxylamine dihydrochloride (CAS 35012-54-5)
- 3-(3-Fluorobenzenesulfonyl)propan-1-ol (CAS 1020734-55-7)
- Semaglutide Impurity 133 (CAS CATO-C4X-2226133)
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