1-[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-yl]ethan-1-one hydrochloride CAS 1251925-25-3
| CAS No. | 1251925-25-3 |
| Molecular Formula | C12H10ClNOS |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-yl]ethan-1-one hydrochloride (CAS 1251925-25-3), molecular formula C12H10ClNOSHCl and molecular weight 288.19 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-yl]ethan-1-one hydrochloride (C12H10ClNOSHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 1-[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-yl]ethan-1-one hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H10ClNOS HCl |
| Molecular Weight | 288.19 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related chlorophenyl Standards
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- N-(2-Chlorophenyl)-5-methyl-1-phenyl-1H-1,2,4-triazole-3-carboxamide (CAS 1000572-01-9)
- N-(2-Chlorophenyl)-5-oxo-1-(p-tolyl)-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide (CAS 1000573-94-3)
- Methyl 1-(2-chlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylate (CAS 1000576-85-1)
- 1-(4-Chlorophenyl)-2,5-dihydro-5-oxo-1H-1,2,4-triazole-3-carboxylic acid phenylamide (CAS 1000577-01-4)
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- 1-(2-Chlorophenyl)-5-oxo-N-phenyl-2,5-dihydro-1H-1,2,4-triazole-3-carboxamide (CAS 1000577-29-6)
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Recommended Standards
- 2,4-Dichlorophenyl chlorothioformate (CAS 2812-86-4)
- 2-(2-Chloroacetamido)-N,N,4-trimethylthiazole-5-carboxamide (CAS 545437-13-6)
- 2-Amino-N-(2-morpholinoethyl)acetamide hydrochloride (CAS 1209052-09-4)
- 2-Amino-N-benzyl-4-phenylthiophene-3-carboxamide (CAS 588692-46-0)
- 4-Cyclopropoxy-2-nitrobenzoic acid (CAS 1243401-70-8)
- 1-((Methylsulfonyl)methyl)naphthalene (CAS 5925-59-7)
- (2E,2'E)-4,4'-(1,2-phenylenebis(azanediyl))bis(4-oxobut-2-enoic acid) (CAS 36847-97-9)
- 1-Cyclopropoxy-2-ethyl-4-methylbenzene (CAS 1243394-87-7)
- 3-((Azetidin-3-yloxy)methyl)-5-isopropyl-1,2,4-oxadiazole (CAS 1340078-98-9)
- Tirzepatide Impurity 19 X TFA Salt (CAS CATO-C4X-324019)
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