2-Iodo-N-methylbenzenesulfonamide CAS 125259-03-2
| CAS No. | 125259-03-2 |
| Molecular Formula | C7H8INO2S |
| Molecular Weight | 297.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Iodo-N-methylbenzenesulfonamide.
2-Iodo-N-methylbenzenesulfonamide (CAS 125259-03-2) is a high-purity analytical reference standard with the molecular formula C7H8INO2S and a molecular weight of 297.11 g/mol.
The molecular framework of 2-Iodo-N-methylbenzenesulfonamide (C7H8INO2S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Iodo-N-methylbenzenesulfonamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H8INO2S |
| Molecular Weight | 297.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Iodo Standards
- 3-Iodo-n-methylbenzenesulfonamide (CAS 1144522-75-7)
- 3-Iodo-2-methylbenzene-1-sulfonamide (CAS 1261554-76-0)
- 5-Iodo-2-methylbenzenesulfonamide (CAS 1261585-10-7)
- 3-Iodo-5-methylbenzene-1-sulfonamide (CAS 1261649-35-7)
- 4-Iodo-N-methylbenzene-1-sulfonamide (CAS 134283-64-0)
- 2-Iodo-4-methylbenzene-1-sulfonamide (CAS 200060-22-6)
- 3-Iodo-4-methylbenzene-1-sulfonamide (CAS 437604-15-4)
- 4-Iodo-3-methylbenzenesulfonamide (CAS 856195-85-2)
Recommended Standards
- 1-(2-Bromo-1-(2,2,2-trifluoroethoxy)ethyl)-2-methylbenzene (CAS 1249851-78-2)
- 1-(2-Bromo-1-(2,2,2-trifluoroethoxy)ethyl)-3-methylbenzene (CAS 1248269-21-7)
- 4-Hydroperoxy Cyclophosphamide-d4 (CAS 1246816-71-6)
- n-(2-Iodophenyl)methanesulfonamide (CAS 116547-92-3)
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- N'-(Furan-2-ylmethylene)-4-methylbenzohydrazide (CAS 113906-79-9)
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- 1-[4-(Aminomethyl)piperidin-1-yl]propan-1-one hydrochloride (CAS 1349699-99-5)
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