3-(Cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine CAS 1254977-87-1
| CAS No. | 1254977-87-1 |
| Molecular Formula | C22H23F3N4 |
| Molecular Weight | 400.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-(Cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine.
3-(Cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine (CAS 1254977-87-1), molecular formula C22H23F3N4 and molecular weight 400.44 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution, 3-(Cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 400.44 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(Cyclopropylmethyl)-7-(4-phenylpiperidin-1-yl)-8-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H23F3N4 |
| Molecular Weight | 400.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Cyclopropylmethyl Standards
- (5Z)-3-{[(cyclopropylmethyl)(propyl)amino]methyl}-5-[(4-oxo-4H-chromen-3-yl)methylidene]-2-sulfanylideneimidazolidin-4-one (CAS 865659-89-8)
- 3-(Cyclopropylmethyl) 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate (CAS 96918-80-8)
- 2-(6-((Cyclopropylmethyl)carbamoyl)-2-(methoxycarbonyl)pyridin-3-yl)-4-methoxy-5-vinylbenzoic acid (CAS 1883265-29-9)
- N-(cyclopropylmethyl)-1-(4-hydroxy-7-(p-tolyl)thieno[3,2-d]pyrimidin-2-yl)piperidine-3-carboxamide (CAS 1242867-13-5)
- cyclopropylmethyl 2-[(4-methylphenyl)thio]-4-(trifluoromethyl)pyrimidine-5-carboxylate (CAS 648859-38-5)
- (5α,6β)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol (1.0mg/ml in Acetonitrile) (CAS 102869-99-8)
- (5α,6α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-(methylamino)-morphinan-3,14-diol (1.0mg/ml in Acetonitrile) (CAS 102919-85-7)
- 3-Benzyl-1-(cyclopropylmethyl)-5-phenyl-1H-benzo[d]imidazol-2(3H)-one (CAS 1359757-43-9)
Recommended Standards
- Boc-Glu(OSu)-OtBu (CAS 81659-82-7)
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1373621-95-4)
- Ticarcillin Impurity 7 (CAS CATO-C4X-17637)
- (6α,9β,11β)-21-(Acetyloxy)-9,11-epoxy-6-fluoro-pregna-1,4,16-triene-3,20-dione (CAS 1817-43-2)
- 3-(4-Fluorophenyl)-1,4-diazaspiro[4.4]Non-3-en-2-one (CAS 899926-75-1)
- 2-(Chloromethyl)-7-(methylthio)benzo[d]oxazole (CAS 1803744-72-0)
- 3-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoyl chloride (CAS 522646-39-5)
- 3-Amino-2-hydroxy-N-(2-hydroxyethyl)benzamide (CAS 473731-23-6)
- N-(1-(pyridin-2-yl)ethyl)tetrahydro-2H-pyran-4-amine (CAS 1157011-33-0)
- Methyl 1-cyclohexyl-5-(4-(methylthio)phenyl)-1H-pyrazole-3-carboxylate (CAS 346684-16-0)
- N-Benzyl-3-bromo-4-methylbenzenesulfonamide (CAS 850429-67-3)
- Ethyl 2-(p-tolyl)propanoate (CAS 78926-01-9)
- 3-Bromo-4-((tetrahydro-2H-pyran-4-yl)oxy)benzoic acid (CAS 1131594-55-2)
- (Tyr?)-C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS 142878-79-3)
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