5,5-Difluoropiperidine-3-carboxylic Acid CAS 1255666-96-6
| CAS No. | 1255666-96-6 |
| Molecular Formula | C6H9F2NO2 |
| Molecular Weight | 165.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5,5-Difluoropiperidine-3-carboxylic Acid is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 5,5-Difluoropiperidine-3-carboxylic Acid (CAS 1255666-96-6), a certified reference material (molecular formula C6H9F2NO2, MW 165.14 g/mol) for analytical method development and quality control.
5,5-Difluoropiperidine-3-carboxylic Acid (C6H9F2NO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H9F2NO2 |
| Molecular Weight | 165.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoropiperidine Standards
- 5,5-Difluoropiperidine-2-carboxylic Acid (CAS 1255663-89-8)
- 4,4-Difluoropiperidine-3-carboxylic acid (CAS 1303973-15-0)
- 4,4-Difluoropiperidine-2-carboxylic acid (CAS 1402664-50-9)
- (2S)-4,4-Difluoropiperidine-2-carboxylic acid (CAS 403503-73-1)
- (S)-5,5-Difluoropiperidine-2-carboxylic acid (CAS 675605-32-0)
- 4,4-Difluoropiperidine-1-ethanamine (CAS 605659-03-8)
- 5,5-Difluoropiperidine-3-carboxamide (CAS 1782200-14-9)
- 3,3-Difluoropiperidine-4,4-diol (CAS 1589565-31-0)
Recommended Standards
- 3,3-Difluoro-4-(hydroxymethyl)piperidin-2-one (CAS 1258639-19-8)
- 3-(3,4-difluorophenyl)prop-2-enenitrile (CAS 1226484-97-4)
- Methyl (2S)-4,4-difluoropyrrolidine-2-carboxylate (CAS 126111-14-6)
- 2,2-Difluoro-N-methoxy-N-methylcyclopropane-1-carboxamide (CAS 1202774-49-9)
- Coronarin D (CAS 119188-37-3)
- 2-(3,5-Difluorophenoxy)-2-methylpropan-1-amine (CAS 1343611-62-0)
- 2-(4-Isopropylphenoxy)-2-methylpropanoic acid (CAS 669747-64-2)
- N-Acetylneuraminic acid methyl ester (CAS 32766-94-2)
- Diphenyl(4-phenylthio)phenylsufonium hexafluorophosphate (CAS 68156-13-8)
- (3-Nitro-1H-1,2,4-triazol-1-yl)methanol (CAS 74205-83-7)
- Ethyl 8-fluoro-4-hydroxy-5-(trifluoromethyl)quinoline-3-carboxylate (CAS 1065102-39-7)
- 3-Amino-N-(1,1-dioxidotetrahydrothiophen-3-yl)propanamide hydrochloride (CAS 1172392-16-3)
- Plazomicin (CAS 1154757-24-0)
- Smac-N7 Peptide (CAS 401913-57-3)
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