6-Bromo-8-fluoro-3,4-dihydro-2H-1,4-benzoxazine CAS 1256255-94-3

Description

The occurrence of 6-Bromo-8-fluoro-3,4-dihydro-2H-1,4-benzoxazine is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

6-Bromo-8-fluoro-3,4-dihydro-2H-1,4-benzoxazine (CAS 1256255-94-3), molecular formula C8H7BrFNO and molecular weight 232.05 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 6-Bromo-8-fluoro-3,4-dihydro-2H-1,4-benzoxazine (C8H7BrFNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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