2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)aniline CAS 1256359-27-9
| CAS No. | 1256359-27-9 |
| Molecular Formula | C13H17BF3NO3 |
| Molecular Weight | 303.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)aniline.
2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)aniline (CAS 1256359-27-9), molecular formula C13H17BF3NO3 and molecular weight 303.09 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)aniline (C13H17BF3NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)aniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H17BF3NO3 |
| Molecular Weight | 303.09 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Tetramethyl Standards
- 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethoxy)pyridine (CAS 1073354-46-7)
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(2,2,2-trifluoroethyl)pyrimidin-2-amine (CAS 1218789-32-2)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethoxy)aniline (CAS 1256360-36-7)
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethoxy)pyridine (CAS 1268467-17-9)
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethoxy)pyridine (CAS 1415748-20-7)
- 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(2,2,2-trifluoroethoxy)pyridine (CAS 1416724-47-4)
- 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethyl)pyridin-2(1H)-one (CAS 1706753-51-6)
- 3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethoxy)aniline (CAS 2088729-74-0)
Recommended Standards
- 2-Methoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine (CAS 1150561-66-2)
- 2-Methoxy-3-(trifluoromethyl)pyridine-5-boronic Acid Pinacol Ester (CAS 1150561-61-7)
- 1-[2-(Dimethylamino)ethyl]-1H-pyrazole-3-carboxylic acid (CAS 1341056-07-2)
- 2-Chloro-N-(2-chloro-3-fluoropyridin-4-yl)-6-fluorobenzamide (CAS 1365991-97-4)
- 4-(5-(4-Fluorophenyl)-1H-imidazol-2-yl)piperidine (CAS 441033-40-5)
- MT-45 diHCl (CAS 57314-55-3)
- 7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (CAS 7752-54-7)
- 2,7-Dinitrothianthrene (CAS 89844-71-3)
- 3-(Methylthio)butan-2-one (CAS 53475-15-3)
- 4-Chloro-5-(4-phenoxyphenyl)-7-(1,4-dioxaspiro[4.5]decan-8-yl)-7h-pyrrolo[2,3-d]pyrimidine (CAS 490030-16-5)
- Methyl 6-cyano-2-methylnicotinate (CAS 1108725-10-5)
- 3,4-Dichloro-5,8-difluoroquinoline (CAS 1204811-35-7)
- 2-(3-Carbethoxy-4-hydroxypyrrolidin-2-on-1-yl)ethyl acetate (CAS 62613-79-0)
- Hexapeptide-10 (CAS 146439-94-3)
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