2-(2-Chloro-5-fluorophenyl)pyrrolidine CAS 1260775-16-3
| CAS No. | 1260775-16-3 |
| Molecular Formula | C10H11ClFN |
| Molecular Weight | 199.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-(2-Chloro-5-fluorophenyl)pyrrolidine (C10H11ClFN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
2-(2-Chloro-5-fluorophenyl)pyrrolidine (CAS 1260775-16-3) is a high-purity analytical reference standard with the molecular formula C10H11ClFN and a molecular weight of 199.65 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H11ClFN |
| Molecular Weight | 199.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 1-(3-Chloro-4-fluorophenyl)pyrrolidine (CAS 1000339-33-2)
- N-[(2-Chloro-4-fluorophenyl)methyl]cyclopropanamine (CAS 1016534-10-3)
- 1-(2-Chloro-6-fluorobenzyl)cyclopropan-1-amine (CAS 1017133-42-4)
- (1-(2-Chloro-6-fluorophenyl)cyclopropyl)methanamine (CAS 1039952-82-3)
- 1-(2-Chloro-6-fluorophenyl)cyclobutanamine (CAS 1094341-12-4)
- 3-Chloro-N-(cyclopropylmethyl)-2-fluoroaniline (CAS 1156168-46-5)
- 5-Chloro-N-(cyclopropylmethyl)-2-fluoroaniline (CAS 1156168-88-5)
- 4-Chloro-N-(cyclopropylmethyl)-2-fluoroaniline (CAS 1157338-17-4)
Recommended Standards
- (S)-2-(4-chloro-3-fluorophenyl)pyrrolidine (CAS 1241680-78-3)
- (S)-1-(3-chloro-4-fluorophenyl)but-3-en-1-amine (CAS 1269780-90-6)
- (R)-2-(2-chloro-6-fluorophenyl)pyrrolidine (CAS 1241677-49-5)
- (R)-1-(4-chloro-3-fluorophenyl)but-3-en-1-amine (CAS 1269803-09-9)
- (3-Fluorocyclohexyl)methanesulfonyl chloride (CAS 1779746-74-5)
- 6-Amino-2-isopropylisoindolin-1-one (CAS 1266949-85-2)
- 15-(Tert-butyl)-2,3,5,6,8,9,11,12-octahydrobenzo[b][1,4,7,10,13]pentaoxacyclopentadecine (CAS 15196-73-3)
- Selexipag-d6 (CAS 1265295-92-8)
- 3-(6-Chloropyridazin-3-yl)aniline (CAS 108810-90-8)
- [4-(Dimethoxymethyl)pyridin-2-yl]boronic acid (CAS 1908439-18-8)
- 2,4,6-Trichlorobiphenyl-2′,3′,4′,5′,6′-d5 (CAS 1219794-85-0)
- 1,4-Bis(trifluoromethyl)-2,3-dihydroxybenzene (CAS 1805519-27-0)
- 2,5-Bis(5-phenyl-2-oxazolyl)pyridine (CAS 40875-87-4)
- Liraglutide Impurity 21 TFA Salt (CAS CATO-C4X-199221)
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